CHLOROBUTYL RUBBER-BASED SELF-RESEALING SEPTUM AND CLOSURE ASSEMBLY

• US 20130245592A1
• Filed: 03/12/2013
• Published: 09/19/2013
• Est. Priority Date: 03/16/2012
• Status: Abandoned Application

• Current Assignee: Fisher Scientific Company LLC (Thermo Fisher Scientific Incorporated)
• Original Assignee: Fisher Scientific Company LLC (Thermo Fisher Scientific Incorporated)
• Inventors: Glaser, John T., Jasko, Mark
• Application Number:
  US13/795,546
• Publication Number:
  US 20130245592A1
• Time in Patent Office: Days
• US Class Current: 604/415
• CPC Class Codes: A61J 1/00 Containers specially adapted for medical or pharmaceutical purposes capsules or the like for oral use A61J3/07; specially adapted for surgical or diagnostic appliances or instruments A61B50/30; containers for radioactive substances G21F5/00
• CPC Class Codes: A61J 1/1406 Septums, pierceable membranes
• CPC Class Codes: A61J 1/1418 Threaded type
• CPC Class Codes: B65D 51/002 Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
• CPC Class Codes: B65D 53/04 Discs
• CPC Class Codes: Y10T 428/24967 Absolute thicknesses specified

Abstract

A self-resealing septum useful in a closure assembly for a container for storing non-aqueous liquids is provided. The septum having a laminate structure including a first layer of a resilient material derived from chlorobutyl rubber and a second layer of a non-elastic polymer. The self-resealing closure assembly includes the septum and a retaining mechanism that is useful for a container assembly that contains a non-aqueous liquid comprising an organic solvent, a liquid organic compound, a water-reactive or oxygen-reactive compound, or a combination thereof.

Claims

1. A septum for use in a self-resealing closure assembly for a container containing a non-aqueous liquid, the septum having a laminate structure comprising:

a first layer of a resilient material derived from halobutyl rubber and having first and second opposed surfaces, wherein the first layer has a first layer thickness between the first and second opposed surfaces within the range from about 1 mm to about 10 mm; and

a second layer of a first non-elastic polymer extending across, and bonded to, the first surface of the first layer, wherein the second layer has a second layer thickness within the range from about 0.03 mm to about 1 mm, wherein the laminate structure of the septum is penetrable by a member in an axial direction and a portion of the laminate structure being configured to elastically distend to pass the member through a tear in the septum and to be self-closing by returning opposite edges of the tear to a substantially contiguous closed condition after withdrawal of the member and which maintains a seal following member penetration in an axial direction and withdrawal, and wherein the septum is used for closing an opening in the container.

2. The septum of claim 1 wherein the first layer is in an initially unbroken condition and the tear is made by rupturing the first layer with the member.

3. The septum of claim 1 further comprising a third layer of a second non-elastic polymer extending across, and bonded to, the second surface of the first layer, wherein the first and the second non-elastomeric polymer are the same or different.

4. The septum of claim 3, wherein at least one of the first non-elastomeric polymer of the second layer, or the second non-elastic polymer of the third layer comprises a fluoropolymer.

5. The septum of claim 4, wherein the fluoropolymer is selected from the group consisting of a polytetrafluoroethylene, a (perfluoroalkoxy) fluoropolymer, and a fluorinated ethylene-propylene polymer.

6. The septum of claim 4, wherein the fluoropolymer is a (perfluoroalkoxy) fluoropolymer.

7. The septum of claim 1, wherein the halobutyl rubber is a chlorobutyl rubber.

8. A self-resealing closure assembly for a container, comprising:

the septum of claim 1, and

a retaining mechanism of inelastic material having an inner and an outer surface, wherein the inner surface of the retaining mechanism is configured to make closing engagement with a rim of the container, and wherein the septum is supported in an opening defined in the retaining mechanism.

9. The self-resealing closure assembly of claim 8, further comprising:

a cap of inelastic material configured to engage with the container or the outer surface of the retaining mechanism.

10. A self-resealing container assembly comprising:

a container;

a non-aqueous liquid comprising an organic solvent, a liquid organic compound, a water-reactive or oxygen-reactive compound, or a combination thereof; and

a self-resealing closure assembly for the container, comprising the septum of claim 1.

11. The container assembly of claim 10, further comprising:

a retaining mechanism of inelastic material having an inner and an outer surface, wherein the inner surface of the retaining mechanism is configured to make closing engagement with a rim of the container, and wherein the septum is supported in an opening defined in the retaining mechanism; and

a cap of inelastic material configured to engage with the container or the outer surface of the retaining mechanism.

12. The container assembly of claim 10, wherein the organic solvent is selected from the group consisting of alcohols, amides, amines, aromatic amines, esters, ethers, hydrocarbons, halogenated hydrocarbons, ketones, nitriles, and sulfoxides.

13. The container assembly of claim 10, wherein the organic solvent is selected from the group consisting of acetone, acetonitrile, chloroform, diethyl ether, dimethylacetamide, dimethylformamide, dimethylsulfoxide, dioxane, ethanol, ethyl acetate, hexane, methanol, N-methylpyrrolidinone, pyridine, tetrahydrofuran, and toluene.

14. The container assembly of claim 10, wherein the non-aqueous liquid comprises a solution or mixture of the organic solvent, and the water-reactive or oxygen-reactive compound, wherein the water-reactive or the oxygen-reactive compound is selected from the group consisting of organometallic compounds, boranes, metal hydrides, Lewis acids, and acid halides.

15. The container assembly of claim 14, wherein the organometallic compound is selected from the group consisting of an organomagnesium compound, an organolithium compound, an organoaluminum compound, and an organozinc compound.

16. The container assembly of claim 10, wherein the liquid organic compound is selected from the group consisting of amines, aldehydes, and phosphines.

17. The container assembly of claim 10, wherein an initial water content of the non-aqueous liquid is equal to or less than about 100 ppm, and wherein after a single occurrence of puncturing the septum with an 18 gauge needle and retracting the 18 gauge needle, the self-resealing container assembly providing less than about 100% increase in water content above the initial water content after storage of the container assembly at ambient conditions for 6 weeks.

18. The container assembly of claim 17, wherein the initial water content is equal to or less than 75 ppm.

19. The container assembly of claim 17, wherein the initial water content is equal to or less than 50 ppm.

20. The container assembly of claim 17, wherein the increase in water content is less than about 50% above the initial water content.

21. The container assembly of claim 17, wherein the increase in water content is less than about 25% above the initial water content.

22. A method of preserving a non-aqueous liquid in a container comprising:

storing the non-aqueous liquid within the self-resealing container assembly of claim 10.