Auto-Injector Device with a Medicated Module
First Claim
1. A drug delivery system for delivering at least three medicaments, the drug delivery system comprising:
- (a) an auto-injector device configured to deliver at least one dose of at least a first and a second medicament, the auto-injector device comprising;
(i) a control unit,(ii) an electro-mechanical drive unit operably coupled to the control unit, the electro-mechanical drive unit also coupled to a first reservoir and a second reservoir containing the first and second medicaments respectively(iii) an operator interface in communication with the control unit, and(iv) an interface hub configured for fluid communication with the first and second reservoirs,wherein activation of the operator interface sets a dose of the first medicament and based on the set dose of the first medicament, the control unit determines a dose of the second medicament based at least in part on a therapeutic dose profile; and
(b) a medicated module attached to the interface hub of the auto-injector device, the medicated module comprising;
(i) an outer housing having an inner surface, a proximal end, and a distal end, wherein the proximal end includes an upper hub holding a first double-ended needle, and wherein the proximal end is connected to the interface hub of the auto-injector drug delivery device,(ii) a bypass housing having an outer surface and slidably engaged with an upper radial stand off on the inner surface of the outer housing,(iii) a reservoir within the bypass housing containing a single dose of a third medicament,(iv) a guard having an internal proximal face and a drive tooth on an inner surface, where the drive tooth is slidably engaged with a track on the outer surface of the bypass housing,(v) a lower hub slidably engaged with the outer surface of the bypass housing and slidably engaged with the inner surface of the guard, wherein the lower hub holds a second double-ended needle, and(vi) a biasing member engaged between the internal proximal face of the guard and the lower hub,wherein the guard is movable between a distal and a proximal position, and wherein movement of the guard in proximal direction causes the bypass housing to move in a proximal direction and causes the reservoir to come into fluid communication with the first and second double ended needles.
1 Assignment
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Accused Products
Abstract
Disclosed herein are various examples of a drug delivery system and corresponding method for delivering three or more medicaments. The system includes two major components: an auto-injector device that contains at least two medicaments and a medicated module that contains at least one medicament. The medicated module interfaces with the auto-injector device such that a combination dose comprising all of the medicaments can be delivered via a single dispense interface of the medicated module. In order to deliver a pre-defined combination dose, a user need only set the dose of one of the medicaments contained in the auto-injector device and need only activate the system once by actuating a dose delivery button on the auto-injector device.
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Citations
19 Claims
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1. A drug delivery system for delivering at least three medicaments, the drug delivery system comprising:
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(a) an auto-injector device configured to deliver at least one dose of at least a first and a second medicament, the auto-injector device comprising; (i) a control unit, (ii) an electro-mechanical drive unit operably coupled to the control unit, the electro-mechanical drive unit also coupled to a first reservoir and a second reservoir containing the first and second medicaments respectively (iii) an operator interface in communication with the control unit, and (iv) an interface hub configured for fluid communication with the first and second reservoirs, wherein activation of the operator interface sets a dose of the first medicament and based on the set dose of the first medicament, the control unit determines a dose of the second medicament based at least in part on a therapeutic dose profile; and (b) a medicated module attached to the interface hub of the auto-injector device, the medicated module comprising; (i) an outer housing having an inner surface, a proximal end, and a distal end, wherein the proximal end includes an upper hub holding a first double-ended needle, and wherein the proximal end is connected to the interface hub of the auto-injector drug delivery device, (ii) a bypass housing having an outer surface and slidably engaged with an upper radial stand off on the inner surface of the outer housing, (iii) a reservoir within the bypass housing containing a single dose of a third medicament, (iv) a guard having an internal proximal face and a drive tooth on an inner surface, where the drive tooth is slidably engaged with a track on the outer surface of the bypass housing, (v) a lower hub slidably engaged with the outer surface of the bypass housing and slidably engaged with the inner surface of the guard, wherein the lower hub holds a second double-ended needle, and (vi) a biasing member engaged between the internal proximal face of the guard and the lower hub, wherein the guard is movable between a distal and a proximal position, and wherein movement of the guard in proximal direction causes the bypass housing to move in a proximal direction and causes the reservoir to come into fluid communication with the first and second double ended needles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A preparation method for delivering a combination of medicaments, the method comprising:
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attaching an interface hub to a distal end of an auto-injector device that contains medicament; attaching a medicated module containing a third medicament, and including a proximal and a distal needle, to a distal end of the interface hub such that the proximal needle of the medicated module is in fluid communication with both the primary and secondary medicaments; setting a desired dose of the main medicament using a dose setter of the auto-injector device; pressing a needle guard of the medicated module against the skin of a user such that the needle guard retracts, thereby placing the distal needle of the medicated module in fluid communication with the medicaments.
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15. A drug delivery system for delivering a combination of medicaments and/or fluids, the drug delivery system comprising:
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an auto-injector device comprising (i) a dose setting mechanism, (ii) a first cartridge containing a first medicament, (iii) an interface hub including an outlet port that is in fluid communication with the cartridge(s), and (iv) a delivery button; and a medicated module attached to a distal end of the interface hub of the auto-injector device, wherein the medicated module includes (i) a reservoir containing a medicament or fluid, (ii) a proximal needle, (iii) a distal needle, and (iv) a slidable needle guard, wherein a pre-defined amount of proximal movement of the needle guard places the distal needle in fluid communication with the first medicament contained in the auto-injector drug delivery device and in fluid communication with the reservoir within the medicated module, wherein a single actuation of the delivery button of the auto-injector device causes a predefined combination dose of medicaments to be delivered via the distal needle of the medicated module, and wherein, during delivery, the first medicament contained in the auto-injector flows through the reservoir of the medicated module, thereby forcing the contents out of the reservoir. - View Dependent Claims (16, 17, 18, 19)
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Specification