ASSESSMENT OF TISSUE OR LESION DEPTH USING TEMPORALLY RESOLVED LIGHT SCATTERING SPECTROSCOPY
First Claim
1. An optical time-resolved method for real-time evaluation of at least one in-vivo cardiac tissue lesion formation parameter, comprising:
- producing a lesion in in-vivo cardiac tissue;
simultaneously with the step of producing a lesion, directing a pulse of optical interrogation radiation onto a first tissue site of said in-vivo cardiac tissue to produce induced radiation;
collecting said induced radiation to produce collected radiation having at least one signal temporal profile of intensity versus time;
quantifying a difference between signal data from said at least one signal temporal profile and reference data from at least one reference temporal profile to produce at least one quantification parameter (QP); and
determining, from said QP, at least one instantaneous condition of said in-vivo cardiac tissue.
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Abstract
A method is described to enhance the ability to evaluate the depth of a tissue component or a lesion having optical properties different from a surrounding tissue using time resolved optical methods. This invention may be particularly suitable for the evaluation of lesion depth during RF ablation (irreversible tissue modification/damage) using specially designed devises (catheters) that deliver heat in a localized region for therapeutic reasons. The technique allows for increased ability to evaluate the depth of the ablated lesion or detect the presence of other processes such as micro-bubble formation and coagulation with higher sensitivity compared to that offered by steady state spectroscopy. The method can be used for in-vivo, real-time monitoring during tissue ablation or other procedures where information on the depth of a lesion or tissue is needed. Exemplary uses are found in tissue ablation, tissue thermal damage, lesion and tissue depth assessment in medical applications.
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Citations
34 Claims
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1. An optical time-resolved method for real-time evaluation of at least one in-vivo cardiac tissue lesion formation parameter, comprising:
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producing a lesion in in-vivo cardiac tissue; simultaneously with the step of producing a lesion, directing a pulse of optical interrogation radiation onto a first tissue site of said in-vivo cardiac tissue to produce induced radiation; collecting said induced radiation to produce collected radiation having at least one signal temporal profile of intensity versus time; quantifying a difference between signal data from said at least one signal temporal profile and reference data from at least one reference temporal profile to produce at least one quantification parameter (QP); and determining, from said QP, at least one instantaneous condition of said in-vivo cardiac tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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Specification