ADAM6 MICE
First Claim
1. A mouse comprising(a) an insertion of one or more human VH, one or more human DH, and one or more human JH gene segments upstream of an endogenous heavy chain constant region;
- and(b) an insertion of one or more human VL and one or more human JL gene segments upstream of an endogenous light chain constant region; and
(c) an ectopic nucleic acid sequence that encodes an Adam6 protein that is functional in the mouse.
2 Assignments
0 Petitions
Accused Products
Abstract
Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.
-
Citations
21 Claims
-
1. A mouse comprising
(a) an insertion of one or more human VH, one or more human DH, and one or more human JH gene segments upstream of an endogenous heavy chain constant region; - and
(b) an insertion of one or more human VL and one or more human JL gene segments upstream of an endogenous light chain constant region; and (c) an ectopic nucleic acid sequence that encodes an Adam6 protein that is functional in the mouse. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
- and
Specification