COFFEE EXTRACTS AS INGREDIENTS OF FOODS, DRUGS, COSMETICS, DIETARY SUPPLEMENTS, AND BIOLOGICS

• US 20130261136A1
• Filed: 10/12/2011
• Published: 10/03/2013
• Est. Priority Date: 10/13/2010
• Status: Abandoned Application

• Current Assignee: Intercontinental Great Brands LLC (Mondelez International, Inc.)
• Original Assignee: Intercontinental Great Brands LLC (Mondelez International, Inc.)
• Inventors: Chu, Yi-Fang, Brown, Peter H., Lyle, Barbara J., Chen, Yumin
• Application Number:
  US13/879,251
• Publication Number:
  US 20130261136A1
• Time in Patent Office: Days
• US Class Current: 514/263.34
• CPC Class Codes: A23L 33/105 Plant extracts, their artificial duplicates or their derivatives
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/302 having a modulating effect on age
• CPC Class Codes: A23V 2200/322 having an effect on the health of the nervous system or on mental function
• CPC Class Codes: A23V 2200/324 having an effect on the immune system
• CPC Class Codes: A23V 2200/328 having effect on glycaemic control and diabetes
• CPC Class Codes: A23V 2250/2108 Caffeine, coffee extract
• CPC Class Codes: A23V 2250/2132 Other phenolic compounds, polyphenols
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/10 General cosmetic use
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 31/35 having six-membered rings with one oxygen as the only ring hetero atom
• CPC Class Codes: A61K 31/522 having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/4953 containing pyrimidine ring derivatives, e.g. minoxidil
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 : for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 39/06 : Free radical scavengers or antioxidants
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/50 : for increasing or potentiating the activity of insulin
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin

Abstract

Embodiments are related to compositions of matter comprising a food, drug, cosmetic, dietary supplement, or biologic product, said product comprised of a phytochemical fraction recovered from a crude caffeine, said phytochemical fraction having a ratio of polyphenols to caffeine of about 20, 10-30 or 40, or greater than 10. In related embodiments, said phytochemical fraction is a retentate of a filtration process of a water suspension of crude caffeine, and wherein said crude caffeine is a product of a green coffee bean decaffeination process. In other related embodiments, said compositions of matter are useful for facilitating neuroprotection, inhibiting COX-2 or stimulating glucose uptake.

Claims

1. A composition of matter comprising a food product, said food product comprised of a phytochemical fraction recovered from a crude caffeine, said phytochemical fraction having a ratio of polyphenols to caffeine of about 20, 10-30 or 40, or greater than 10.

2. The composition of matter of claim 1, wherein said phytochemical fraction is a retentate of a filtration process of a water suspension of crude caffeine, and wherein said crude caffeine is a product of a green coffee bean decaffeination process.

3. A process for producing a food product comprising either supplementing a food with, or supplementing a component of a food with, a phytochemical fraction recovered from a crude caffeine, said phytochemical fraction being that as described in claim 1, whereby said food product is produced.

16. A process for facilitating neuroprotection, said process comprising:

a. Identifying a human subject in need of neuroprotection; and

b. Administering an amount of the composition of claim 1 to said subject effective to facilitate neuroprotection.

17. A process for facilitating neuroprotection, said process comprising:

a. Administering an amount of the composition of claim 1 to a human subject effective to facilitate neuroprotection; and

b. Measuring neuroprotection in said subject.

18. A process for inhibiting COX-2, said process comprising:

a. Identifying a human subject in need of inhibition of COX-2; and

b. Administering an amount of the composition of claim 1 to said subject effective to inhibit COX-2.

19. A process for inhibiting COX-2, said process comprising:

a. Administering an amount of the composition of claim 1 to a human subject effective to inhibit COX-2; and

b. Measuring inhibition of COX-2 in said subject.

20. A process for stimulating glucose uptake, said process comprising:

a. Identifying a human subject in need of stimulation of glucose uptake; and

b. Administering an amount of the composition of claim 1 to said subject effective to stimulate glucose uptake.

21. A process for stimulating glucose uptake, said process comprising:

a. Administering an amount of the composition of claim 1 to a human subject effective to stimulate glucose uptake; and

b. Measuring stimulation of glucose uptake in said subject.

22. A process for treating dementia or age related cognitive decline, said process comprising:

a. Identifying a human subject in need of treatment of dementia or age related cognitive decline; and

b. Administering an amount of the composition of claim 1 to said subject effective to treat dementia or age related cognitive decline.

23. A process for treating dementia or age related cognitive decline, said process comprising:

a. Administering an amount of the composition of claim 1 to a human subject effective to treat dementia or age related cognitive decline; and

b. Measuring treatment of dementia or age related cognitive decline in said subject.

24. A process for inhibiting inflammation, said process comprising:

a. Identifying a human subject in need of inhibition of inflammation; and

b. Administering an amount of the composition of claim 1 to said subject effective to inhibit inflammation.

25. A process for inhibiting inflammation, said process comprising:

a. Administering an amount of the composition of claim 1 to a human subject effective to inhibit inflammation; and

b. Measuring inhibition of inflammation in said subject.

26. A process for treating diabetes mellitus, said process comprising:

a. Identifying a human subject in need of treatment of diabetes mellitus; and

b. Administering an amount of the composition of claim 1 to said subject effective to treat diabetes mellitus.

27. A process for treating diabetes mellitus, said process comprising:

a. Administering an amount of the composition of claim 1 to a human subject effective to treat diabetes mellitus; and

b. Measuring treatment of diabetes mellitus in said subject.

28. The process of claim 16, wherein the identifying step or the measuring step is by neuropsychological testing.

29. The process of claim 18, wherein the identifying step or the measuring step is by rheumatology criteria.

30. The process of claim 20, wherein the identifying step or the measuring step is by blood glucose concentration.

4. A composition of matter comprising a drug product, said drug product comprised of a phytochemical fraction recovered from a crude caffeine, said phytochemical fraction having a ratio of polyphenols to caffeine of about 20, 10-30 or 40, or greater than 10.

5. The composition of matter of claim 4, wherein said phytochemical fraction is a retentate of a filtration process of a water suspension of crude caffeine, and wherein said crude caffeine is a product of a green coffee bean decaffeination process.

6. A process for producing a drug product comprising either supplementing a drug with, or supplementing a component of a drug with, a phytochemical fraction recovered from a crude caffeine, said phytochemical fraction being that as described in claim 4, whereby said drug product is produced.

7. A composition of matter comprising a cosmetic product, said cosmetic product comprised of a phytochemical fraction recovered from a crude caffeine, said phytochemical fraction having a ratio of polyphenols to caffeine of about 20, 10-30 or 40, or greater than 10.

8. The composition of matter of claim 7, wherein said phytochemical fraction is a retentate of a filtration process of a water suspension of crude caffeine, and wherein said crude caffeine is a product of a green coffee bean decaffeination process.

9. A process for producing a cosmetic product comprising either supplementing a cosmetic with, or supplementing a component of a cosmetic with, a phytochemical fraction recovered from a crude caffeine, said phytochemical fraction being that as described in claim 7, whereby said cosmetic product is produced.

10. A composition of matter comprising a dietary supplement product, said dietary supplement product comprised of a phytochemical fraction recovered from a crude caffeine, said phytochemical fraction having a ratio of polyphenols to caffeine of about 20, 10-30 or 40, or greater than 10.

11. The composition of matter of claim 10, wherein said phytochemical fraction is a retentate of a filtration process of a water suspension of crude caffeine, and wherein said crude caffeine is a product of a green coffee bean decaffeination process.

12. A process for producing a dietary supplement product comprising either supplementing a dietary supplement with, or supplementing a component of a dietary supplement with, a phytochemical fraction recovered from a crude caffeine, said phytochemical fraction being that as described in claim 10, whereby said dietary supplement product is produced.

13. A composition of matter comprising a biologic product, said biologic product comprised of a phytochemical fraction recovered from a crude caffeine, said phytochemical fraction having a ratio of polyphenols to caffeine of about 20, 10-30 or 40, or greater than 10.

14. The composition of matter of claim 13, wherein said phytochemical fraction is a retentate of a filtration process of a water suspension of crude caffeine, and wherein said crude caffeine is a product of a green coffee bean decaffeination process.

15. A process for producing a biologic product comprising either supplementing a biologic with, or supplementing a component of a biologic with, a phytochemical fraction recovered from a crude caffeine, said phytochemical fraction being that as described in claim 13, whereby said biologic product is produced.