NANOPARTICLES BASED ON POLY (LACTIC GLYCOLIC) ACID FOR COSMETIC APPLICATIONS

• US 20130266625A1
• Filed: 01/24/2012
• Published: 10/10/2013
• Est. Priority Date: 01/24/2011
• Status: Abandoned Application

• Current Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (Hebrew University of Jerusalem)
• Original Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (Hebrew University of Jerusalem)
• Inventors: Nasser, Taher, Karra, Nour, Benita, Simon, Badihi, Amit
• Application Number:
  US13/995,259
• Publication Number:
  US 20130266625A1
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 2800/10 General cosmetic use
• CPC Class Codes: A61K 2800/412 Microsized, i.e. having sizes between 0.1 and 100 microns
• CPC Class Codes: A61K 2800/413 Nanosized, i.e. having sizes below 100 nm
• CPC Class Codes: A61K 2800/56 Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
• CPC Class Codes: A61K 31/573 substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• CPC Class Codes: A61K 31/575 substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• CPC Class Codes: A61K 38/13 Cyclosporins
• CPC Class Codes: A61K 38/23 Calcitonins
• CPC Class Codes: A61K 38/28 Insulins
• CPC Class Codes: A61K 39/3955 against proteinaceous materials, e.g. enzymes, hormones, lymphokines
• CPC Class Codes: A61K 49/0054 Macromolecular compounds, i.e. oligomers, polymers, dendrimers
• CPC Class Codes: A61K 8/11 Encapsulated compositions
• CPC Class Codes: A61K 8/85 Polyesters
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/146 with organic macromolecular compounds
• CPC Class Codes: A61K 9/1647 Polyesters, e.g. poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/5031 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/04 Antipruritics
• CPC Class Codes: A61P 17/06 : Antipsoriatics
• CPC Class Codes: A61P 17/12 : Keratolytics, e.g. wart or anti-corn preparations
• CPC Class Codes: A61P 27/00 : Drugs for disorders of the senses
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin
• CPC Class Codes: C07C 323/57 : the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
• CPC Class Codes: Y10T 428/2982 : Particulate matter [e.g., sphere, flake, etc.]

Abstract

On one hand, the present invention relates to cosmetic compositions comprising poly(lactic glycolic)acid (PLGA) nanoparticles for applications to the skin. On the other hand, it also concerns polymeric nanoparticles having on its surface a plurality of cosmetically active agents, each of said agents being associated to said nanoparticle via oleylcysteineamide, delivery systems for topical application based on said particles and cosmetic formulations comprising said particles.

Claims

1. A cosmetic composition comprising poly(lactic glycolic)acid (PLGA) nanoparticles and a cosmetically acceptable carrier, the nanoparticles having an averaged diameter of at most 500 nm, the PLGA having an averaged molecular weight of between 2,000 and 20,000 Da.

2. The composition according to claim 1, wherein the nanoparticles are associated with at least one agent selected from the group consisting of a cosmetically-active agent and non-active agent.

4. The composition according to claim 2, wherein said at least one cosmetically-active agent is selected from the group consisting of a vitamin, a protein, an anti-oxidant, a peptide, a polypeptide, a lipid, a carbohydrate, a hormone, a prophylactic agent, a nutraceutical agent, a small molecule of a molecular weight of less than about 1,000 Da or less than about 500 Da, an electrolyte, a drug, a hydrophilic macromolecule, a lipophilic macromolecule, a macromolecule having molecular weight higher than 1.000 Da, and any combination of the aforementioned.

8. The composition according to claim 4, wherein the at least one cosmetically-active agent is a macromolecule selected from the group consisting of hyaluronic acid, collagen and DHEA.

12. The composition according to claim 2, wherein said non-active agent is selected to modulate one or more characteristic of the nanoparticle, said characteristic being selected from the group consisting of size, polarity, hydrophobicity/hydrophilicity, electrical charge, reactivity, chemical stability, clearance and targeting.

15. The composition according to claim 12, wherein the non-active agent is a fatty amino acid (alkyl amino acid).

18. The composition according to claim 2, wherein the at least one agent is associated with said nanoparticle via a chemical association selected from the group consisting of covalent bonding, electrostatic bonding, and hydrogen bonding, or via a physical association of at least a portion of the agent with the nanoparticle.

20. The composition according to claim 2, wherein the at least one agent is associated with the surface of said nanoparticle.

21. The composition of claim 20, wherein the at least one agent is at least one hydrophilic agent.

22. The composition according to claim 2, wherein the at least one cosmetically-active agent is associated with the surface of the nanoparticle via one or more linker moieties.

23. The composition according to claim 22, wherein said one or more linker moieties having a first portion capable of association with the nanoparticle and a second portion capable of association with the cosmetically-active agent.

26. The composition according to claim 23, wherein the linker is oleylcysteineamide.

29. The composition according to claim 2, wherein said at least one agent is associated to be contained within a core of said nanoparticle or within a matrix of said nanoparticle.

30. The composition according to claim 29, wherein said at least one agent is at least one lipophilic agent.

31. The composition according to claim 2, wherein at least one agent is associated with the surface of the nanoparticle and at least one different agent is associated to be contained within a core of said nanoparticle or within a matrix of said nanoparticle.

43. The composition according to claim 1, wherein the nanoparticles consist essentially of PLGA.

44. The composition according to claim 1, wherein the cosmetically acceptable carrier is a silicone-based carrier.

56. The composition according to claim 1, wherein the PLGA polymer is a copolymer of polylactic acid (PLA) and polyglycolic acid (PGA), the molar ratio of PLA to PGA being selected from the group consisting of 95:

5, 90;

10, 85;

15, 80;

20.75;

25, 70;

30, 65;

35, 60;

40, 55;

45, and 50;

50.

67. The composition of claim 1, being essentially free of water.

3. (canceled)

5-7. -7. (canceled)

9-11. -11. (canceled)

13. (canceled)

14. (canceled)

16. (canceled)

17. (canceled)

19. (canceled)

24. (canceled)

25. (canceled)

27. (canceled)

28. (canceled)

32-42. -42. (canceled)

45-55. -55. (canceled)

57-66. -66. (canceled)

68. A polymeric nanoparticle having on its surface a plurality of cosmetically-active agents, each of said agents being associated to said nanoparticle via oleylcysteineamide.

72. A delivery system for topical application, the system comprising:

(i) a polymeric nanoparticle according to claim 68; and

(ii) at least one agent associated with said nanoparticle, said at least one agent being optionally associated with the nanoparticle surface via a linker moiety.

69-71. -71. (canceled)

73-81. -81. (canceled)