LIQUID PHARMACEUTICAL COMPOSITION FOR THE DELIVERY OF ACTIVE INGREDIENTS
First Claim
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1. A pharmaceutical composition in the form of a suspension comprising:
- (a) particles of an active ingredient, said ingredient being present in a therapeutically effective amount, and(b) a liquid vehicle comprising a semifluorinated alkane of the formula RFRH wherein RF is a linear perfluorinated hydrocarbon segment with 3 to 10 carbon atoms, and wherein RH is a linear alkyl group with 3 to 10 carbon atoms.
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Abstract
The invention provides novel pharmaceutical compositions based on semifluorinated alkanes which are useful as carriers for a broad range of active ingredients. Preferred active ingredients include poorly water-soluble and/or hydrolytically sensitive drug substances. The compositions are designed as suspensions and have superior physical properties which make them highly useful as pharmaceutical delivery systems. The compositions may be administered topically into the eye, or injected via the subcutaneous or intramuscular route. The invention further provides kits comprising such compositions.
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Citations
20 Claims
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1. A pharmaceutical composition in the form of a suspension comprising:
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(a) particles of an active ingredient, said ingredient being present in a therapeutically effective amount, and (b) a liquid vehicle comprising a semifluorinated alkane of the formula RFRH wherein RF is a linear perfluorinated hydrocarbon segment with 3 to 10 carbon atoms, and wherein RH is a linear alkyl group with 3 to 10 carbon atoms. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification