PHARMACEUTICAL COMPOSITIONS COMPRISING FATTY ACID ESTERS
First Claim
Patent Images
1. A pharmaceutical composition comprising:
- (a) a water-insoluble antipsychotic agent;
(b) a C1-6 alkyl ester of a C10-20 fatty acid;
(c) a polyoxy ethylene derivative of a sorbitan ester of a carboxylic acid, wherein the carboxylic acid comprises 8-20 carbon atoms; and
(d) an aqueous vehicle;
wherein the composition forms an aqueous, flocculated, injectable suspension.
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Abstract
The present invention relates to an injectable, pharmaceutical composition comprising a C1-6 alkyl ester of a C10-20 fatty acid. In an embodiment, the fatty acid is ethyl oleate, isopropyl oleate, ethyl myristate, or isopropyl myristate. These compositions are useful for the delivery of anti-psychotic drugs.
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Citations
45 Claims
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1. A pharmaceutical composition comprising:
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(a) a water-insoluble antipsychotic agent; (b) a C1-6 alkyl ester of a C10-20 fatty acid; (c) a polyoxy ethylene derivative of a sorbitan ester of a carboxylic acid, wherein the carboxylic acid comprises 8-20 carbon atoms; and (d) an aqueous vehicle; wherein the composition forms an aqueous, flocculated, injectable suspension. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 12, 13, 14, 15, 16, 17, 20, 44)
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10-11. -11. (canceled)
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18-19. -19. (canceled)
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21. (canceled)
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22. An injectable pharmaceutical composition comprising:
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(a) olanzapine, aripiprazole, a compound of formula I, II, III, IV, V, VI, or pharmaceutically acceptable salts, hydrates, or solvates thereof; (b) a C1-6 alkyl ester of a C10-20 fatty acid; (c) polysorbate 20; and (d) an aqueous carrier. - View Dependent Claims (23)
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24-26. -26. (canceled)
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27. An injectable pharmaceutical composition comprising:
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(a) olanzapine, aripiprazole, a compound of formula I, II, III, IV, V, VI, or pharmaceutically acceptable salts, hydrates, or solvates thereof; (b) ethyl oleate, isopropyl oleate, ethyl myristate, or isopropyl myristate; (c) polysorbate 20; and (d) an aqueous carrier. - View Dependent Claims (28)
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29-43. -43. (canceled)
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45-50. -50. (canceled)
Specification