PHARMACEUTICAL COMPOSITIONS COMPRISING BENZYL ALCOHOL
First Claim
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1. A pharmaceutical composition comprising:
- (a) a water-insoluble antipsychotic agent;
(b) benzyl alcohol;
(c) a polyoxyethylene derivative of a sorbitan ester of a carboxylic acid, wherein the carboxylic acid comprises 8-14 carbon atoms; and
(d) an aqueous vehicle;
wherein the composition forms an aqueous, flocculated, injectable suspension.
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Abstract
The present invention relates to a pharmaceutical composition comprising benzyl alcohol and polyoxyethylene derivatives of sorbitan esters of carboxylic acids that are useful for the delivery of anti-psychotic drugs.
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Citations
37 Claims
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1. A pharmaceutical composition comprising:
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(a) a water-insoluble antipsychotic agent; (b) benzyl alcohol; (c) a polyoxyethylene derivative of a sorbitan ester of a carboxylic acid, wherein the carboxylic acid comprises 8-14 carbon atoms; and (d) an aqueous vehicle; wherein the composition forms an aqueous, flocculated, injectable suspension. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 15, 18, 36)
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9. (canceled)
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14. (canceled)
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16-17. -17. (canceled)
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19-21. -21. (canceled)
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22. An injectable pharmaceutical composition comprising:
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(a) aripiprazole, or olanzapine, or a compound of formula I, II, III, IV, V, VI, or pharmaceutically acceptable salts, hydrates, or solvates thereof, wherein component (a) is in a weight ratio of approximately 15-35%; (b) benzyl alcohol in a weight ratio of approximately 1-4% (c) polysorbate 20 in a weight ratio of approximately 0.05-0.8%; and (d) an aqueous carrier.
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23-24. -24. (canceled)
- 25. An injectable composition comprising a water-insoluble antipsychotic agent and benzyl alcohol.
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26-28. -28. (canceled)
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30. (canceled)
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32. (canceled)
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34-35. -35. (canceled)
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37-42. -42. (canceled)
Specification