TRANSCUTANEOUS ANALYTE SENSOR

• US 20130267808A1
• Filed: 05/28/2013
• Published: 10/10/2013
• Est. Priority Date: 07/13/2004
• Status: Abandoned Application

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Brister, Mark, Kline, Daniel S., Masterson, Steve, Saint, Sean
• Application Number:
  US13/903,609
• Publication Number:
  US 20130267808A1
• Time in Patent Office: Days
• US Class Current: 600/345
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2560/0252 using ambient temperature
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/1411 by percutaneous method, e.g. by lancet
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/6833 Adhesive patches
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: A61B 5/6849 in combination with a needle set
• CPC Class Codes: A61B 5/743 Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots
• CPC Class Codes: A61M 5/158 Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body

Abstract

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Claims

1. A system for measuring an analyte in a host, comprising:

an on-skin assembly comprising;

an electronics unit;

a mounting unit releasably matable to the electronics unit; and

a sensor comprising;

an in vivo portion adapted for insertion through an exit port of the mounting unit and through an exit site of the host'"'"'s skin; and

an ex vivo portion adapted to remain above the host'"'"'s skin after insertion of the in vivo portion and to operably connect to the electronics unit,

wherein the electronics unit, when releasably mated to the mounting unit, together comprise a subassembly that has a volume of less about 8 cm³ and a thickness of less than about 10 mm, whereby motion artifacts cased by motion of the subassembly translating to the sensor in vivo is reduced as compared to a subassembly that has a volume of greater than about 8 cm³ and a thickness of greater than about 10 mm.

2. The system of claim 1, wherein the electronics unit, when releasably mated to the mounting unit, together comprise a subassembly that has a volume of less about 6 cm³ and a thickness of less than about 9 mm, whereby motion artifacts caused by motion of the subassembly translating to the sensor in vivo is reduced as compared to a subassembly that has a volume of greater than about 6 cm³ and a thickness of greater than about 9 mm.

3. The system of claim 1, wherein the electronics unit and housing each comprise a mutually engaging electrical contact.

4. The system of claim 1, wherein the mounting unit comprises an elastomeric sealing member for sealing the operable connection of the sensor with the electronics unit.

5. The system of claim 1, wherein the sensor exits the mounting unit at an edge or near an edge of the device.

6. The system of claim 1, wherein the electronics unit is configured to slide-fit into the mounting unit.

7. The system of claim 1, wherein the applicator is configured to slide-fit into the mounting unit.

8. The system of claim 1, wherein the applicator comprises an automated spring-loaded mechanism configured to apply a continuous torque to insert the sensor.

9. The system of claim 1, wherein the electronics unit comprises an ASIC.

10. The system of claim 9, wherein the ASIC comprises a data sampling portion.

11. The system of claim 9, wherein the ASIC comprises a transmitter portion.

12. The system of claim 1, wherein the system is configured such that use of the system beyond a predetermined time period is prevented.

13. The system of claim 12, wherein the system is configured to render the sensor inoperative after the predetermined time period.

14. The system of claim 12, wherein the system is configured to render the sensor inoperative in response to release of the mating of the electronics unit with the mounting unit.