SYSTEMS AND METHODS FOR DISEASE KNOWLEDGE MODELING
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Accused Products
Abstract
Systems and methods are described herein for disease knowledge modeling and clinical treatment decision support, and the prioritization of possible treatment options based on tumor or other disease biomarkers. Disease or indication information, including identification of biomolecular entities associated with the indication may be culled through text data mining to create a knowledge model of the indication. In some embodiments, the knowledge model may comprise a network of associations between molecular entities, including such drug targets and biomakers, genes, pathways. The model may be combined with patient-specific variant information and historical treatment records to identify and prioritize treatment decisions and allow for the prediction of disease drivers and provide treatment options tailored to a patient'"'"'s genetic data.
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Citations
92 Claims
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1-45. -45. (canceled)
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46. A method for prioritizing treatment decisions, comprising:
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retrieving, by an analyzer executed by a processor of a computing device, an identification of a patient indication; identifying, by the analyzer, a plurality of proteins or genes associated with the patient indication, and at least one genetic variant associated with the patient indication; selecting, by the analyzer, a subset of the plurality of proteins or genes responsive to an identified functional impact of the genetic variant on the protein or gene associated with the patient identification; generating, by the analyzer, an indication-specific molecular entity network based on the selected subset of the plurality of proteins or genes; retrieving, by the analyzer from a medication information database, an identification of a plurality of medications having one or more targets in the indication-specific molecular entity network; and generating, by the analyzer, a prioritized list of suggested treatments, each comprising one or more of the plurality of medications, wherein the priority of a suggested treatment depends on a number of targets in the indication-specific molecular entity network affected by the one or more medications of the suggested treatment. - View Dependent Claims (47, 48, 49, 50, 51, 52, 53, 54, 55)
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56. A system for prioritizing treatment decisions, comprising:
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a computing device comprising a processor and a memory, the processor executing an analyzer configured for; retrieving an identification of a patient indication; identifying a plurality of proteins or genes associated with the patient indication, and at least one genetic variant associated with the patient indication; selecting a subset of the plurality of proteins or genes responsive to an identified functional impact of the genetic variant on the protein or gene associated with the patient identification; generating an indication-specific molecular entity network based on the selected subset of the plurality of proteins or genes; retrieving, from a medication information database, an identification of a plurality of medications having one or more targets in the indication-specific molecular entity network; and generating a prioritized list of suggested treatments, each comprising one or more of the plurality of medications, wherein the priority of a suggested treatment is dependent on a number of targets in the indication-specific molecular entity network affected by the one or more medications of the suggested treatment. - View Dependent Claims (57, 58, 59, 60, 61, 62, 63, 91, 92)
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64-90. -90. (canceled)
Specification