METHOD AND SYSTEM FOR DRUG DELIVERY

• US 20130276799A1
• Filed: 12/22/2011
• Published: 10/24/2013
• Est. Priority Date: 12/22/2010
• Status: Active Grant

• Current Assignee: Syqe Medical Ltd.
• Original Assignee: Exonoid Medical Devices Ltd.
• Inventors: Davidson, Perry, Holtz, Arie, Schorr, Aaron, Pong, Will
• Granted Patent: US 9,775,379 B2
• Time in Patent Office: Days
• US Class Current: 131/273
• CPC Class Codes: A24F 40/10 Devices using liquid inhalable precursors
• CPC Class Codes: A24F 40/20 Devices using solid inhalable precursors
• CPC Class Codes: A24F 40/485 Valves; Apertures
• CPC Class Codes: A24F 40/50 Control or monitoring
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/007 Pulmonary tract; Aromatherapy
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61M 11/041 using heaters
• CPC Class Codes: A61M 11/042 electrical
• CPC Class Codes: A61M 11/048 with a flame, e.g. using a burner
• CPC Class Codes: A61M 15/0003 with means for dispensing more than one drug
• CPC Class Codes: A61M 15/0016 located downstream of the dispenser, i.e. traversed by the product
• CPC Class Codes: A61M 15/002 with air flow regulating means
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/0051 the dosages being arranged on a tape, e.g. strips
• CPC Class Codes: A61M 15/0055 the used dosages being coiled
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/0066 with means for varying the dose size
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 15/0081 Locking means
• CPC Class Codes: A61M 15/0083 : Timers
• CPC Class Codes: A61M 2016/0021 : with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2016/0039 : in the inspiratory circuit
• CPC Class Codes: A61M 2202/062 : Desiccants
• CPC Class Codes: A61M 2205/12 : with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/13 : with means for the detection of operative contact with patient, e.g. lip sensor
• CPC Class Codes: A61M 2205/17 : with redundant control systems
• CPC Class Codes: A61M 2205/18 : with alarm
• CPC Class Codes: A61M 2205/276 : preventing unwanted use
• CPC Class Codes: A61M 2205/3306 : Optical measuring means
• CPC Class Codes: A61M 2205/3331 : Pressure; Flow
• CPC Class Codes: A61M 2205/3365 : Rotational speed
• CPC Class Codes: A61M 2205/3368 : Temperature
• CPC Class Codes: A61M 2205/3553 : remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3584 : using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/3592 : using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/3606 : cooled
• CPC Class Codes: A61M 2205/364 : by chemical reaction
• CPC Class Codes: A61M 2205/3653 : by Joule effect, i.e. electric resistance
• CPC Class Codes: A61M 2205/3673 : thermo-electric, e.g. Peltier effect, thermocouples, semi-conductors
• CPC Class Codes: A61M 2205/368 : by electromagnetic radiation, e.g. IR waves
• CPC Class Codes: A61M 2205/502 : User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/52 : with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/581 : by audible feedback
• CPC Class Codes: A61M 2205/583 : by visual feedback
• CPC Class Codes: A61M 2205/587 : Lighting arrangements
• CPC Class Codes: A61M 2205/60 : with identification means
• CPC Class Codes: A61M 2205/6009 : for matching patient with his treatment, e.g. to improve transfusion security
• CPC Class Codes: A61M 2205/6018 : providing set-up signals for the apparatus configuration
• CPC Class Codes: A61M 2205/6054 : Magnetic identification systems
• CPC Class Codes: A61M 2205/6063 : Optical identification systems
• CPC Class Codes: A61M 2205/6072 : Bar codes
• CPC Class Codes: A61M 2205/8206 : battery-operated
• CPC Class Codes: A61M 2207/00 : Methods of manufacture, assembly or production
• CPC Class Codes: A61M 2209/06 : Packaging for specific medical equipment
• CPC Class Codes: A61M 2209/10 : Equipment for cleaning
• CPC Class Codes: G16H 20/13 : delivered from dispensers

Abstract

There is provided in accordance with an exemplary embodiment of the invention, a device and a method for controlled extraction of at least one active substance from at least one type of plant matter by application of heat, the device comprising: a heating element adapted to apply heat to an area of the plant matter to extract the substance; and a mechanism adapted for moving the plant matter relative to the heating element. Optionally, the active substance is a restricted substance. There is also provided in accordance with an exemplary embodiment of the invention, a method of monitoring and controlling inhalation of a restricted substance. There is provided in accordance with an exemplary embodiment of the invention, a method of manufacturing a tape of plant matter comprising an active substance.

Claims

1. A device for controlled extraction of at least one active substance from at least one type of plant matter by application of heat, said device comprising:

a layer containing plant matter; and

a heating element adapted to apply heat to an area of said plant matter to extract said substance; and

a delivery tract for delivery of air to a user;

characterized in that said layer is configured such that air may flow from behind said layer, through said layer, and to said delivery tract.

2. The device according to claim 1, wherein said layer is configured as a tape, said plant matter comprising said active substance.

3. The device according to claim 1, wherein said active substance is a restricted substance.

4. The device according to claim 1, wherein said active substance is selected from the group comprising:

tetrahydrocannabinol, salvinorin A, benzoylmethylecgonine, dimethyltryptamine, psilocybin.

5. The device according to claim 1, wherein said plant matter is organized with a predetermined amount of said active substance per unit area of said layer.

6. The device according to claim 1, wherein a thickness of said layer ranges from about 0.2 mm to about 1.0 mm.

7. The device according to claim 1, wherein said layer comprises about 5 milligrams to about 50 grams of said plant matter.

8. The device according to claim 1, wherein said layer comprises a sufficient amount of said active substance for at least one treatment dose.

9. The device according to claim 1, wherein said layer is organized as a roll.

10. The device according to claim 1, wherein said layer comprises a first material layer coupled to said plant matter at a side opposite that contacting said heating element, said first layer comprising apertures large enough to let air containing said extracted substance escape but small enough to contain residue of said heated plant matter.

11. The device of claim 10, wherein a diameter of said apertures ranges from 25 μ

m-500 μ

m.

12. The device of claim 10, wherein said layer comprises a second material layer coupled to said plant matter at least at a side contacting said heating element, said second layer adapted to transmit heat to said plant matter without substantially distributing the heat across said second layer.

13. The device according to claim 1, wherein an area of said heating element ranges from about 10 mm² to about 100 mm².

14. The device according to claim 1, further comprising an inhaler unit adapted to connect and disconnect from said device, said inhaler unit comprising:

a mouthpiece for inhalation of said substance, said mouthpiece forming fluid communication with a vapor chamber upon said connection of said inhaler unit and said device, said vapor chamber comprising said extracted active substance.

15. The device of claim 14, wherein said mouthpiece comprises a one way valve to control fluid flow away from said vapor chamber.

16. The device of claim 14, further comprising a sensor in fluid communication with said mouthpiece, said sensor adapted to estimate an air flow rate and send a signal to a controller, said controller adapted for extracting said substance according to said airflow rate.

17. The device of claim 1, further comprising a controller configured to synchronize said application of heat and said movement of said plant matter.

18. The device according to claim 1, further comprising circuitry for controlling activation of said heating element.

19. The device according to claim 1, further comprising a communication interface for communicating to one or more external computers.

20. The device according to claim 1, further comprising a dose display meter for providing visual output of said extraction of said substance.

21-73. -73. (canceled)