CHIMERIC ANTIGEN RECEPTOR FOR BISPECIFIC ACTIVATION AND TARGETING OF T LYMPHOCYTES
First Claim
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1. A cell comprising a chimeric antigen receptor (CAR) comprising two or more non-identical antigen recognition domains.
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Abstract
Embodiments of the invention include methods and compositions related to improved cells encoding a chimeric antigen receptor that is specific for two or more antigens. In certain aspects the receptor encompasses two or more non-identical antigen recognition domains. The antigens are tumor antigens, in particular embodiments.
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Citations
27 Claims
- 1. A cell comprising a chimeric antigen receptor (CAR) comprising two or more non-identical antigen recognition domains.
- 18. An expression vector encoding a CAR comprising two or more non-identical antigen recognition domains.
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27. A kit comprising cells comprising a chimeric antigen receptor (CAR) comprising two or more non-identical antigen recognition domains and/or expression vector encoding a CAR comprising two or more non-identical antigen recognition domains.
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