SYSTEM AND METHOD FOR TREATING A MEDICAL CONDITION USING AN AEROSOLIZED SOLUTION

• US 20130284165A1
• Filed: 04/26/2013
• Published: 10/31/2013
• Est. Priority Date: 04/27/2012
• Status: Abandoned Application

• Current Assignee: Medstar Health
• Original Assignee: Medstar Health
• Inventors: Krimsky, William S.
• Application Number:
  US13/871,291
• Publication Number:
  US 20130284165A1
• Time in Patent Office: Days
• US Class Current: 128/200.14
• CPC Class Codes: A61M 11/00 Sprayers or atomisers specially adapted for therapeutic purposes in general B05B; aerosol containers B65D83/14
• CPC Class Codes: A61M 11/005 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 16/0063 Compressors
• CPC Class Codes: A61M 16/0066 Blowers or centrifugal pumps
• CPC Class Codes: A61M 16/0078 Breathing bags
• CPC Class Codes: A61M 16/009 Removing used or expired gases or anaesthetic vapours filtering, sterilising or disinfecting the exhaust air in drainage systems A61M1/784; bacterial filters in the expiratory path A61M16/1065
• CPC Class Codes: A61M 16/08 Bellows; Connecting tubes having means for taking samples G01N1/22; Water traps; Patient circuits
• CPC Class Codes: A61M 16/0833 T- or Y-type connectors, e.g. Y-piece
• CPC Class Codes: A61M 16/0891 Closed circuit, e.g. for anaesthesia
• CPC Class Codes: A61M 16/1075 by influencing the temperature A61M16/1045 takes precedence
• CPC Class Codes: A61M 16/16 Devices to humidify the respiration air A61M16/1045 takes precedence
• CPC Class Codes: A61M 16/202 electrically actuated
• CPC Class Codes: A61M 16/204 used for inhalation control
• CPC Class Codes: A61M 16/208 Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
• CPC Class Codes: A61M 19/00 Local anaesthesia syringes therefor A61M5/00; Hypothermia A61M5/42 takes precedence; cooling blood in a bypass of the arterial system A61M1/36
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2016/1035 the anaesthetic agent concentration
• CPC Class Codes: A61M 2202/03 Gases in liquid phase, e.g. cryogenic liquids
• CPC Class Codes: A61M 2205/3368 : Temperature
• CPC Class Codes: A61M 2205/3606 : cooled
• CPC Class Codes: A61M 2205/50 : with microprocessors or computers
• CPC Class Codes: A61M 2230/43 : Composition of exhalation

Abstract

A system for treating a medical condition in a subject using an aerosolized solution includes a subject interface, an inspiratory limb in fluid communication with the subject interface, an expiratory limb in fluid communication with the subject interface, and a controller in electrical communication with the inspiratory and expiratory limbs. The inspiratory limb includes an aerosol-generating device configured to provide the aerosolized solution. The controller is configured to automatically regulate at least one treatment parameter based on feedback from one or more sensors operably integrated into the inspiratory limb and/or the expiratory limb. The at least one treatment parameter is selected from the group consisting of the amount, rate, and temperature of the aerosolized solution.

Claims

1. A system for treating a medical condition in a subject using an aerosolized solution, said system comprising:

a subject interface;

an inspiratory limb in fluid communication with said subject interface, said inspiratory limb including an aerosol-generating device configured to provide the aerosolized solution;

an expiratory limb in fluid communication with said subject interface; and

a controller in electrical communication with said inspiratory and expiratory limbs, said controller configured to automatically regulate at least one treatment parameter based on feedback from one or more sensors operably integrated into said inspiratory limb and/or said expiratory limb, said at least one treatment parameter being selected from the group consisting of the amount, rate, and temperature of the aerosolized solution.

2. The system of claim 1, further comprising a Y-connector having a first port configured to mate with said subject interface, a second port configured to mate with an end of said expiratory limb, and a third port configured to mate with an end of said aerosol-generating device.

3. The system of claim 1, said inspiratory limb further including:

a coolant or cryogen source;

a humidifier; and

a first sensor for sensing the temperature of a coolant or cryogen being delivered to the subject.

4. The system of claim 1, said expiratory limb further including a second sensor for sensing the temperature of the gas being exhaled from the subject.

5. The system of claim 1, said expiratory limb comprising a valve in fluid communication with at least one port configured to convey an exhaled gas therethrough.

6. The system of claim 1, wherein said aerosol-generating device further includes an aerosol-generating mechanism to improve aerosolization of a therapeutic liquid or solution and increase delivery efficiency of the aerosolized solution into the subject.

7. The system of claim 1, wherein said aerosol-generating mechanism includes a vortex chamber, a vibratory mesh, or a combination thereof.

8. The system of claim 1, wherein said controller includes software configured to maintain the core temperature of the subject based on feedback from said one or more sensors.

9. A system for regulating the body temperature of a subject using an aerosolized solution, said system comprising:

a subject interface;

an inspiratory limb in fluid communication with said subject interface, said inspiratory limb including a aerosol-generating device configured to provide the aerosolized solution;

an expiratory limb in fluid communication with said subject interface;

a controller in electrical communication with said inspiratory and expiratory limbs, said controller configured to automatically regulate at least one treatment parameter based on feedback from one or more sensors operably integrated into said inspiratory limb and/or said expiratory limb, said at least one treatment parameter being selected from the group consisting of the amount, rate, and temperature of the aerosolized solution; and

a Y-connector having a first port configured to mate with said subject interface, a second port configured to mate with an end of said expiratory limb, and a third port configured to mate with an end of said aerosol-generating device;

wherein said aerosol-generating device further includes an aerosol-generating mechanism to improve aerosolization of a therapeutic liquid or solution and increase delivery efficiency of the aerosolized solution into the subject.

10. The system of claim 9, wherein said aerosol-generating mechanism includes a vortex chamber, a vibratory mesh, or a combination thereof.

11. The system of claim 9, said inspiratory limb further including:

a coolant or cryogen source;

a humidifier; and

a first sensor for sensing the temperature of a coolant or cryogen being delivered to the subject.

12. The system of claim 9, said expiratory limb further including a second sensor for sensing the temperature of the gas being exhaled from the subject.

13. The system of claim 9, said expiratory limb comprising a valve in fluid communication with at least one port configured to convey an exhaled gas therethrough.

14. The system of claim 9, wherein said controller includes software configured to maintain the core temperature of the subject based on feedback from said one or more sensors.

15. A method for treating a medical condition in a subject, said method comprising the steps of:

providing a system including a subject interface, an inspiratory limb in fluid communication with the subject interface, an expiratory limb in fluid communication with the subject interface, and a controller in electrical communication with the inspiratory and expiratory limbs;

operably coupling the subject interface to the subject; and

delivering an aerosolized solution from the system to the subject in an amount and for a time sufficient to treat the medical condition;

wherein the controller automatically regulates at least one treatment parameter based on feedback from one or more sensors operably integrated into the inspiratory limb and/or the expiratory limb, the at least one treatment parameter being selected from the group consisting of the amount, rate, and temperature of the aerosolized solution.

16. The method of claim 15, wherein delivery of the aerosolized solution induces and maintains hypothermia in the subject.

17. The method of claim 15, wherein the aerosolized solution is delivered to the subject following an ischemic event.

18. The method of claim 15, wherein the aerosolized solution is delivered to the subject to treat cancer.

19. The method of claim 15, wherein the aerosolized solution is a nebulized solution.

20. The method of claim 15, wherein the aerosolized solution is an atomized solution.