Drug Delivery System And Method For Conscious Sedation/Analgesia
First Claim
1. A method for delivery of a mixture to a patient effective to produce analgesia without loss of consciousness in a patient wherein the method comprises:
- a) forming a gaseous mixture of oxygen and a halogenated material selected from the group consisting of halogenated ethers and halothane by mixing oxygen with the halogenated material in a delivery manifold, the manifold having a controller configured to provide a gas having a concentration of the halogenated material that is limited to not more than about 0.636 MAC; and
b) controlling the proportions of oxygen and halogenated material in the gaseous mixture by metering a liquid flow of the halogenated material into a gas containing the oxygen such that the gaseous mixture comprises a ratio of oxygen to halogenated material effective for producing analgesia without loss of consciousness in the patient;
c) delivering said gaseous mixture to the patient to produce analgesia without loss of consciousness in the patient; and
d) performing a medical or dental intervention or procedure during analgesia while the patient is conscious.
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Accused Products
Abstract
Inhalant anesthetics are developed with a number of properties including rapid onset and recovery, controllability, and, ideally, a broad safety profile. The efficacy of these agents is measured by their ability to create anesthesia within the framework of the other desirable properties. The instant invention focuses on the dosage level where analgesia occurs but amnesia or lack of consciousness does not. In addition to identifying the dosage level where pain is sharply reduced or eliminated but awareness remains, a delivery system for safe and effective delivery of the agent is described.
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Citations
24 Claims
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1. A method for delivery of a mixture to a patient effective to produce analgesia without loss of consciousness in a patient wherein the method comprises:
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a) forming a gaseous mixture of oxygen and a halogenated material selected from the group consisting of halogenated ethers and halothane by mixing oxygen with the halogenated material in a delivery manifold, the manifold having a controller configured to provide a gas having a concentration of the halogenated material that is limited to not more than about 0.636 MAC; and b) controlling the proportions of oxygen and halogenated material in the gaseous mixture by metering a liquid flow of the halogenated material into a gas containing the oxygen such that the gaseous mixture comprises a ratio of oxygen to halogenated material effective for producing analgesia without loss of consciousness in the patient; c) delivering said gaseous mixture to the patient to produce analgesia without loss of consciousness in the patient; and d) performing a medical or dental intervention or procedure during analgesia while the patient is conscious. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A system for delivering gas to a patient to produce analgesia without loss of consciousness in the patient comprising:
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a) an oxygen source; b) a reservoir suitable for storing a liquid phase of an analgesia producing agent, the agent being a halogenated material selected from the group consisting of halogenated ethers and halothane; c) a delivery manifold having a pair of inputs connected to the oxygen source and to the reservoir, respectively, and having an output, the manifold providing a gaseous mixture of oxygen and the analgesia producing agent by metering a flow of the liquid halogenated material into the oxygen, the manifold having a controller configured to provide the gaseous mixture such that the halogenated material is limited to not more than about 0.636 MAC for producing analgesia without loss of consciousness; and d) means for conveying the gaseous mixture from the output of the delivery manifold to a patient for producing analgesia without loss of consciousness in the patient while a medical or dental intervention or procedure is carried out. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 24)
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- 18. A drug delivery system having a reservoir to provide halogenated material, the halogenated material being selected from the group consisting of halogenated ethers and halothane, wherein the reservoir is suitable for storing the halogenated material in a liquid phase, and a delivery manifold for providing a gaseous mixture of oxygen and the halogenated material by metering a flow of the liquid halogenated material into the oxygen, the manifold including a controller configured to provide a concentration of the halogenated material in a gas phase that is limited to not more than about 0.636 MAC for producing analgesia without loss of consciousness in a patient that is undergoing a medical or dental intervention or procedure.
Specification