THERAPY SYSTEMS INCLUDING HYPERTHERMIC ENERGY DELIVERY ELEMENTS AND CRYOGENIC APPLICATORS AND ASSOCIATED METHODS
First Claim
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1. A treatment device, comprising:
- a shaft including a proximal portion and a distal portion, wherein the shaft is configured to insert the distal portion at a treatment site at least proximate a renal artery;
a therapeutic assembly extending from the distal portion of the shaft, the therapeutic assembly comprising—
an energy delivery element configured to apply therapeutically-effective hyperthermic energy to tissue at the treatment site to modulate renal nerves proximate the treatment site; and
a cryogenic applicator configured to cool tissue at least proximate the treatment site.
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Abstract
Therapy systems for hyperthermic energy delivery and cryogenic cooling and associated methods of use. A treatment device can have a distal portion with a therapeutic assembly including an energy delivery element and a cryogenic applicator. The energy delivery element can be configured to apply therapeutically-effective hyperthermic energy to a treatment site (e.g., for neuromodulation). The cryogenic applicator can be configured to cool tissue at least proximate the treatment site.
38 Citations
27 Claims
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1. A treatment device, comprising:
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a shaft including a proximal portion and a distal portion, wherein the shaft is configured to insert the distal portion at a treatment site at least proximate a renal artery; a therapeutic assembly extending from the distal portion of the shaft, the therapeutic assembly comprising— an energy delivery element configured to apply therapeutically-effective hyperthermic energy to tissue at the treatment site to modulate renal nerves proximate the treatment site; and a cryogenic applicator configured to cool tissue at least proximate the treatment site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A treatment device, comprising:
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a shaft including a proximal portion and a distal portion, wherein the shaft is configured to insert the distal portion at a treatment site at least proximate a renal artery; an energy delivery element attached to the distal portion of the shaft and configured to deliver therapeutically-effective energy that modulates nerves that innervate the kidney, wherein the energy delivery element is configured to be operably coupled to a hyperthermic energy source positioned at the proximal portion of the shaft; and a cryogenic applicator attached to the distal portion of the shaft and in fluid communication with a refrigerant source positioned at the proximal portion of the shaft. - View Dependent Claims (10, 11, 12, 13, 14)
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15. A method of treating a patient, comprising:
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inserting a therapeutic assembly to a treatment site in a renal artery, wherein the therapeutic assembly extends from a distal portion of an elongated shaft; cooling a zone at least proximate the treatment site using a cryogenic applicator of the therapeutic assembly; and applying therapeutically-effective hyperthermic energy to the treatment site to cause renal nerve modulation using an energy delivery element of the therapeutic assembly. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method of treating a patient, comprising:
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locating a therapeutic assembly at a treatment site at least proximate a renal artery, wherein the therapeutic assembly is at a distal portion of an elongated shaft; applying therapeutically-effective cryogenic cooling at the treatment site using a cryogenic applicator of the therapeutic assembly to modulate nerves that innervate the kidney; freezing at least a portion of the cryogenic applicator to tissue at the treatment site to form a temporary frozen attachment; and applying hyperthermic energy at least proximate the temporary frozen attachment using an energy delivery element of the therapeutic assembly to thaw the frozen attachment.
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Specification