SYSTEMS AND METHODS FOR PERFORMING CORRELATION ANALYSIS ON CLINICAL OUTCOME AND CHARACTERISTICS OF BIOLOGICAL TISSUE
First Claim
1. A computer-implemented method for correlating one or more features of biological tissue with a clinical outcome, the method comprising:
- rendering a graphical user interface on a visual display device;
rendering, on the graphical user interface, a field of view selection component allowing a user to select a field of view from a data set of a cohort comprising tissue profile data including multiplexed biomarker images capturing expression of a plurality of biomarkers in a plurality of fields of view of biological tissue;
in response to user input selecting a first biomarker and a first field of view corresponding to a biological tissue at the field of view selection component, rendering, on the graphical user interface, a first image of the selected first field of view corresponding to the biological tissue, the first image representing expression levels of the selected first biomarker and including representations of one or more biological units in the biological tissue;
receiving, at the graphical user interface, a selection of a clinical outcome and a selection of a first set of one or more of the biological units in the biological tissue;
selectively displaying or highlighting the selected first set of biological units represented on the first image; and
automatically determining and displaying a result of a correlation analysis performed between one or more features of the selected first set of biological units in the cohort and the selected clinical outcome.
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Accused Products
Abstract
Embodiments disclosed herein include methods, systems, and devices for determining a positive or negative correlation between a clinical outcome and one or more features of biological tissue. An exemplary user interface enables a user to select a clinical outcome and one or more aspects of a displayed field-of-view of biological tissue. Exemplary embodiments may automatically perform correlation analysis between the selected clinical outcome and one or more features characteristic of the user-selected aspects of the field-of-view of biological tissue. For example, exemplary embodiments may automatically perform correlation analysis between the selected clinical outcome and one or more features characteristic of one or more biological units in the biological tissue.
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Citations
21 Claims
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1. A computer-implemented method for correlating one or more features of biological tissue with a clinical outcome, the method comprising:
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rendering a graphical user interface on a visual display device; rendering, on the graphical user interface, a field of view selection component allowing a user to select a field of view from a data set of a cohort comprising tissue profile data including multiplexed biomarker images capturing expression of a plurality of biomarkers in a plurality of fields of view of biological tissue; in response to user input selecting a first biomarker and a first field of view corresponding to a biological tissue at the field of view selection component, rendering, on the graphical user interface, a first image of the selected first field of view corresponding to the biological tissue, the first image representing expression levels of the selected first biomarker and including representations of one or more biological units in the biological tissue; receiving, at the graphical user interface, a selection of a clinical outcome and a selection of a first set of one or more of the biological units in the biological tissue; selectively displaying or highlighting the selected first set of biological units represented on the first image; and automatically determining and displaying a result of a correlation analysis performed between one or more features of the selected first set of biological units in the cohort and the selected clinical outcome. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A computer-implemented method for correlating one or more features of biological tissue with a clinical outcome, the method comprising:
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rendering a graphical user interface on a visual display device; rendering, on the graphical user interface, a field of view selection component allowing a user to select a field of view from a data set of a cohort comprising tissue profile data including multiplexed biomarker images capturing expression of a plurality of biomarkers in a plurality of fields of view of biological tissue; in response to user input selecting a first biomarker and a first field of view corresponding to a biological tissue at the field of view selection component, rendering, on the graphical user interface, a first image of the selected first field of view corresponding to the biological tissue, the first image representing expression levels of the selected first biomarker and including representations of one or more biological units in the biological tissue; receiving, at the graphical user interface, a selection of a first set of one or more of the biological units in the biological tissue; selectively displaying or highlighting the selected first set of biological units represented on the first image; and automatically determining and displaying a result of a correlation analysis performed between a clinical outcome and one or more features in the data set of the cohort that are characteristic of the selected first set of biological units. - View Dependent Claims (19)
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20. A computer system for correlating one or more features of biological tissue with a clinical outcome, the system comprising:
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a visual display device; a data storage device for storing a data set of a cohort comprising tissue profile data including multiplexed biomarker images capturing expression of a plurality of biomarkers in a plurality of fields of view of biological tissue; and a computer processor programmed to; render a graphical user interface on the visual display device, render, on the graphical user interface, a field of view selection component allowing a user to select a field of view from the data set stored on the data storage device, in response to user input selecting a first biomarker and a first field of view corresponding to a biological tissue at the field of view selection component, render, on the graphical user interface, a first image of the selected first field of view corresponding to the biological tissue, the first image representing expression levels of the selected first biomarker and including representations of one or more biological units in the biological tissue, receive, at the graphical user interface, a selection of a clinical outcome and a selection of a first set of one or more of the biological units in the biological tissue, selectively display or highlight the selected first set of biological units represented on the first image, and automatically determine and display a result of a correlation analysis performed between one or more features of the selected first set of biological units in the cohort and the selected clinical outcome.
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21. A computer system for correlating one or more features of biological tissue with a clinical outcome, the system comprising:
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a visual display device; a data storage device for storing a data set of a cohort comprising tissue profile data including multiplexed biomarker images capturing expression of a plurality of biomarkers in a plurality of fields of view of biological tissue; and a computer processor programmed to; render a graphical user interface on the visual display device, render, on the graphical user interface, a field of view selection component allowing a user to select a field of view from the data set stored on the data storage device, in response to user input selecting a first biomarker and a first field of view corresponding to a biological tissue at the field of view selection component, render, on the graphical user interface, a first image of the selected first field of view corresponding to the biological tissue, the first image representing expression levels of the selected first biomarker and including representations of one or more biological units in the biological tissue, receive, at the graphical user interface, a selection of a first set of one or more of the biological units in the biological tissue, selectively display or highlight the selected first set of biological units represented on the first image, and automatically determine and display a result of a correlation analysis performed between a clinical outcome and one or more features in the data set of the cohort that are characteristic of the selected first set of biological units.
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Specification