SOLVENT-CAST MICROPROTRUSION ARRAYS CONTAINING ACTIVE INGREDIENT
First Claim
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1. A method of making a microstructure array, comprising:
- dispensing onto a mold having an array of microstructure cavities a formulation comprising a polymer, a therapeutic agent and a solvent, said formulation dispensed in an amount sufficient to at least partially fill the microstructure cavities, said dispensing carried out in the presence of a gas having a solubility in the formulation or the mold that is greater than the solubility of air in the formulation or the mold;
drying the formulation; and
demolding from the mold a microstructure array.
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Abstract
In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
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Citations
19 Claims
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1. A method of making a microstructure array, comprising:
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dispensing onto a mold having an array of microstructure cavities a formulation comprising a polymer, a therapeutic agent and a solvent, said formulation dispensed in an amount sufficient to at least partially fill the microstructure cavities, said dispensing carried out in the presence of a gas having a solubility in the formulation or the mold that is greater than the solubility of air in the formulation or the mold; drying the formulation; and demolding from the mold a microstructure array. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification