OPEN CELLED FOAMS, IMPLANTS INCLUDING THEM AND PROCESSES FOR MAKING SAME

• US 20130295379A1
• Filed: 07/10/2013
• Published: 11/07/2013
• Est. Priority Date: 01/28/2010
• Status: Abandoned Application

• Current Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Original Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Inventors: Thompson, Jordan, Van Epps, Dennis, Goraltchouk, Alexei
• Application Number:
  US13/939,141
• Publication Number:
  US 20130295379A1
• Time in Patent Office: Days
• US Class Current: 428/338
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: B32B 5/16 characterised by features of a layer formed of particles, e.g. chips, powder or granules layer formed of natural mineral particles B32B19/00; layer being formed of wood fibres, chips or particles B32B21/02
• CPC Class Codes: B32B 5/18 characterised by features of a layer of foamed material
• CPC Class Codes: C08J 2201/046 Elimination of a polymeric phase
• CPC Class Codes: C08J 2201/0502 the liquid phase being organic
• CPC Class Codes: C08J 2205/05 Open cells, i.e. more than 50% of the pores are open
• CPC Class Codes: C08J 2207/10 Medical applications, e.g. biocompatible scaffolds
• CPC Class Codes: C08J 2383/04 Polysiloxanes
• CPC Class Codes: C08J 9/26 by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
• CPC Class Codes: C08J 9/28 by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: Y10T 428/249921 Web or sheet containing structurally defined element or component
• CPC Class Codes: Y10T 428/268 Monolayer with structurally defined element

Abstract

Described herein are open celled foams including a matrix of interconnected spheres. Also described herein are methods of making open celled foams as well as making composite members with open celled foam coatings covering at least a portion of the composite member. The open celled foams described herein are silicone based materials and can be used to coat implants such as breast implants and function to encourage tissue ingrowth and reduce capsular formation.

Claims

1. An open celled foam comprising:

a matrix of interconnected spheres, said spheres comprising substantially pure silicone.

2. The open celled foam of claim 1 made by the process of:

combining a first composition comprising a first organic solvent and at least one extractable agent, and a second composition comprising a second organic solvent and at least one silicone matrix agent thereby forming a mixture, wherein said at least one matrix agent is less than about 40% of said mixture;

agitating said mixture thereby forming an emulsion; and

curing said emulsion thereby forming said open celled foam including a matrix of interconnected spheres.

3. The open celled foam of claim 1 wherein said matrix of interconnected spheres has a theoretical void space of about 60% and about 88%.

4. The open celled foam of claim 1 wherein said matrix of interconnected spheres has a physical void space of about 50% to about 70%.

5. The open celled foam of claim 1 wherein said spheres have a diameter of between about 25 μ

m and about 200 μ

m.