OPHTHALMIC COMPOSITIONS WITH IMPROVED DESSICATION PROTECTION AND RETENTION

• US 20130296264A1
• Filed: 05/03/2013
• Published: 11/07/2013
• Est. Priority Date: 05/04/2012
• Status: Abandoned Application

• Current Assignee: Alcon Research Limited (Nestle SA)
• Original Assignee: Alcon Research Limited (Nestle SA)
• Inventors: Davis, James W., Ketelson, Howard Allen, Meadows, David L., Rangarajan, Rekha, Campbell, Elaine E.
• Application Number:
  US13/886,788
• Publication Number:
  US 20130296264A1
• Time in Patent Office: Days
• US Class Current: 514/54
• CPC Class Codes: A61K 31/728 Hyaluronic acid
• CPC Class Codes: A61K 31/736 Glucomannans or galactomannans, e.g. locust bean gum, guar gum
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 27/04 Artificial tears; Irrigation solutions

Abstract

The present invention relates to artificial tear compositions and ophthalmic compositions suitable for drug delivery. In one embodiment of the present invention, the compositions comprise a galactomannan polymer such as guar or hydroxypropyl guar, hyaluronic acid, and a cis-diol such as sorbitol. In a preferred embodiment, the compositions also comprise a borate compound.

Claims

1. An ophthalmic composition comprising 0.1 to 0.2 w/v % galactomannan, 0.05 to 0.5 w/v % hyaluronic acid, and 1.0 to 2.0 w/v % cis-diol.

2. A composition according to claim 1 comprising 0.17 to 0.18 w/v % guar, 0.13 to 0.17 w/v % sodium hyaluronate, and 1.4 w/v % sorbitol.

3. A composition according to claim 1 wherein said galactomannan is selected from the group consisting of:

guar, hydroxylpropyl guar, and combinations thereof.

4. A composition according to claim 1 wherein said cis-diol is selected from the group consisting of sorbitol, mannitol, polyethylene glycols, polypropylene glycols, polyethyleneoxide-polybutyleneoxide block copolymers, and combinations thereof.

5. A composition according to claim 1 wherein said cis-diol is sorbitol or mannitol.

6. A composition according to claim 5 wherein said cis-diol is present at a concentration of about 1.4 w/v %.

7. A composition according to claim 1 wherein said borate is boric acid.

8. A composition according to claim 1 further comprising a demulcent selected from the group consisting of:

glycerin, polyvinyl pyrrolidone, polyethylene oxide, polyethylene glycol, propylene glycol, polyacrylic acid, and combinations thereof.

9. A composition according to claim 8 wherein said demulcent is polypropylene glycol or polyethylene glycol.

10. A composition according to claim 1 further comprising a pharmaceutically active compound.

11. A method for treating ophthalmic disease which comprises administering to a subject in need of such treatment a composition according to claim 1.

12. A method according to claim 10, wherein the ophthalmic disease is dry eye.