HEDGEHOG PATHWAY MODULATORS
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Abstract
The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).
5 Citations
51 Claims
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1-31. -31. (canceled)
- 32. A compound having the structure of Formula I:
Specification