High-Throughput Immune Sequencing
3 Assignments
0 Petitions
Accused Products
Abstract
Methods and compositions for determining and/or monitoring the immune state of an individual are provided.
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Citations
61 Claims
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1-35. -35. (canceled)
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36. A method for identifying a therapeutic antibody, comprising:
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(a) linking polynucleotide sequences encoding a VH and a VL isolated from a single cell of a plurality of cells from a single subject to form paired sequences; (b) sequencing polynucleotides amplified from the paired sequences; (c) determining the frequency of two or more paired VH and VL sequences; (d) determining a variance from a reference library of the paired sequences from (c); and (e) identifying a therapeutic antibody based on (c) and (d). - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61)
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Specification