Endoluminal Drug Applicator and Method of Treating Diseased Vessels of the Body
First Claim
1. An apparatus for delivering a therapeutic agent to a treatment site of a vessel, valve, duct or bowel, the apparatus comprising:
- a) a first elongate flexible member having a distal end; and
b) a stent-graft coupled to said flexible member at or near the distal end of said flexible member and configurable from a collapsed configuration to an expanded configuration, said stent-graft including,i) an expandable stent fixed to said flexible member, wherein a portion of said expandable stent defines a generally tubular structure in said expanded configuration,ii) a porous polymeric mesh that interfaces circumferentially about said portion of said stent and is expandable with said stent, andiii) at least one therapeutic agent carried by said mesh, wherein when said stent-graft is in said expanded configuration and contacts the treatment site, said at least one therapeutic agent is transferred to the treatment site by operation of contact between said stent-graft and the treatment site.
1 Assignment
0 Petitions
Accused Products
Abstract
A stent-graft is coupled to an elongate flexible member at or near the distal end of the flexible member and configurable in both a collapsed configuration and an expanded configuration. The stent-graft includes an expandable stent fixed to the flexible member. A portion of the expandable stent defines a generally tubular structure in its expanded configuration. A porous polymeric mesh interfaces circumferentially about the portion of the stent defines a generally tubular structure. The mesh is expandable with the stent and carries at least one therapeutic agent. When the stent-graft is in its expanded configuration and contacts the treatment site, the at least one therapeutic agent is transferred to the treatment site by operation of contact between the stent-graft and the treatment site. The mesh can define distal and proximal openings that allow for fluid flow through the stent-graft when the stent-graft is in the expanded configuration.
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Citations
28 Claims
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1. An apparatus for delivering a therapeutic agent to a treatment site of a vessel, valve, duct or bowel, the apparatus comprising:
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a) a first elongate flexible member having a distal end; and b) a stent-graft coupled to said flexible member at or near the distal end of said flexible member and configurable from a collapsed configuration to an expanded configuration, said stent-graft including, i) an expandable stent fixed to said flexible member, wherein a portion of said expandable stent defines a generally tubular structure in said expanded configuration, ii) a porous polymeric mesh that interfaces circumferentially about said portion of said stent and is expandable with said stent, and iii) at least one therapeutic agent carried by said mesh, wherein when said stent-graft is in said expanded configuration and contacts the treatment site, said at least one therapeutic agent is transferred to the treatment site by operation of contact between said stent-graft and the treatment site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A surgical method for delivering at least one therapeutic agent to a treatment site of a vessel, valve, duct or bowel, the method comprising:
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a) providing a stent-graft configurable in both a collapsed configuration and an expanded configuration, said stent-graft including, i) an expandable stent, wherein a portion of said expandable stent defines a generally tubular structure in said expanded configuration, ii) a porous polymeric mesh that interfaces circumferentially about said portion of said stent and expandable with said stent, and iii) at least one therapeutic agent carried by said mesh; and b) locating said stent-graft at the treatment site in said expanded configuration such that it contacts the treatment site, whereby said at least one therapeutic agent is transferred to the treatment site by operation of contact between said stent-graft and the treatment site, wherein said mesh defines distal and proximal openings that allow for fluid flow through said stent-graft when said stent-graft is in said expanded configuration. - View Dependent Claims (27, 28)
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Specification