System and Method for Measurement of Physiological Data with Light Modulation

• US 20130303921A1
• Filed: 05/11/2012
• Published: 11/14/2013
• Est. Priority Date: 05/11/2012
• Status: Abandoned Application

• Current Assignee: Hong Kong Applied Science And Technology Research Institute Co., Ltd.
• Original Assignee: Hong Kong Applied Science And Technology Research Institute Co., Ltd.
• Inventors: ZHANG, Chun, CHU, Lut Hey, KWOK, Ka Cheung
• Application Number:
  US13/469,094
• Publication Number:
  US 20130303921A1
• Time in Patent Office: Days
• US Class Current: 600/473
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/113 occurring during breathing
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters

Abstract

The present invention discloses a device for measuring physiological data of a subject. It comprises a light modulation unit, an optical detection unit and a signal processing unit. The present invention can operate in an active mode or a passive mode to measure a subject'"'"'s heart rate, respiratory information, haemoglobin level, cardiac output or oxygen saturation of the blood, etc. Fourier Transform based lock-in technique is used to detect the physiological signals reliably even when the signal is weak. In addition, ambient light can be used as the light source to complete the measurement.

Claims

1. A device for measuring physiological data of a subject comprising:

a) a light modulation unit for generating at least one modulated light signal by modulating at least one light source at at least one predefined frequency, said at least one modulated light signal being generated before irradiation onto said subject and each said at least one modulated light signal having a different wavelength;

b) an optical detection unit for receiving a composite spectrophotometric light signal and converting said composite spectrophotometric light signal into an electrical signal, said composite spectrophotometric light signal being generated when a physiological signal of said subject is regulated by said at least one modulated light signal; and

c) a signal processing unit adapted for;

i) converting said electrical signal into a digital signal;

ii) obtaining a frequency spectrum of said digital signal;

iii) tracking at least one dominant spectral peak of said frequency spectrum, each said dominant spectral peak corresponding to each said at least one predefined frequency;

iv) recognizing at least one minor spectral peak at said frequency spectrum from the vicinity of said at least one dominant spectral peak; and

v) determining said physiological data from said at least one dominant spectral peak and said at least one minor spectral peak.

2. The device of claim 1 wherein said light modulation unit comprises an electronic circuit that turns said at least one light source on and off at said at least one predefined frequency.

3. The device of claim 1, wherein said at least one modulated light signal further comprises a first modulated light signal emitting red light at a first predefined frequency and a second modulated light signal emitting infra-red light at a second predefined frequency.

4. The device of claim 1 wherein said light modulation unit comprises a wheel, said wheel being opaque to light and comprising at least one hollow area for allowing light to pass through, said wheel rotating at a predetermined frequency so that light emitted from said at least one light source is intermittently transmitted and blocked and thus is modulated at said at least one predefined frequency, said predefined frequency being an integer multiple of said predetermined frequency.

5. The device of claim 4 wherein said at least one hollow area being coupled to a color filter that only allows light with certain wavelength to pass through.

6. The device of claim 5 wherein said at least one light source being ambient light.

7. The device of claim 1 wherein said light modulation unit comprising:

a) a static disc with at least one color filter thereon which only allows light with certain wavelength to pass through; and

b) a wheel with at least one hollow area;

said static disc being coupled to said wheel, said wheel rotating at a predetermined frequency and said static disc being stationary in which said at least one color filter and said at least one hollow area align along an axis intermittently when said wheel rotates so that light emitted from said at least one light source is intermittently transmitted and blocked and thus is modulated at said at least one predefined frequency, said predefined frequency being an integer multiple of said predetermined frequency.

8. The device in claim 1 wherein said signal processing unit further comprises an analog-to-digital convertor, a central processing unit and memory, said processing unit executing an embedded program stored in said memory for determining said physiological data.

9. The device of claim 1, wherein said physiological data being heart rate, heart rate variability, respiratory information, haemoglogin level, arterial stiffness index, cardiac output, oxygen saturation of the blood, or any combination thereof.

10. The device of claim 1 further comprising an optical collection unit for said device to operate in a non-contact environment;

said optical collection unit being an optical fiber, a lens, a mirror or a waveguide for directing said composite spectrophotometric light signal to said optical detection unit.

11. The device of claim 1 wherein said optical detection unit comprises a device selected from a photodiode, a photomulitplier tube, a CMOS array and a CCD array.

12. An apparatus for measuring physiological data of a subject comprising:

a) a light modulation unit for generating at least one modulated light signal by modulating an ambient light reflected from said subject at at least one predefined frequency, each said at least one modulated light signal having a different wavelength;

b) an optical detection unit for receiving a composite spectrophotometric light signal and converting said composite spectrophotometric light signal into an electrical signal, said composite spectrophotometric light signal being generated when a physiological signal of said subject is regulated by said at least one modulated light signal;

c) a processing unit for determining said physiological data from said electrical signal.

13. The apparatus of claim 12, wherein said light modulation unit comprises a wheel which is opaque to light, said wheel comprising at least one hollow area coupled to a color filter for allowing light with certain wavelength to pass through, said wheel rotating at a predetermined frequency so that said ambient light being modulated at said at least one predefined frequency, said predefined frequency being an integer multiple of said predetermined frequency.

14. The apparatus of claim 12, wherein said light modulation unit comprising:

a) a static disc with at least one color filter thereon which only allows light with certain wavelength to pass through; and

b) a wheel with at least one hollow area;

said static disc being coupled to said wheel, said wheel rotating at a predetermined frequency and said static disc being stationary in which said at least one color filter and said at least one hollow area align along an axis intermittently when said wheel rotates so that said ambient light being modulated at said at least one predefined frequency, said predefined frequency being an integer multiple of said predetermined frequency.

15. The apparatus of claim 12, wherein said processing unit is adapted for:

a) converting said electrical signal into a digital signal;

b) obtaining a frequency spectrum of said digital signal;

c) tracking at least one dominant spectral peak at said frequency spectrum, each said dominant spectral peak corresponding to each said at least one predefined frequency;

d) recognizing at least one minor spectral peak at said frequency spectrum from the vicinity of said at least one spectral peak; and

e) determining said physiological data from said at least one dominant spectral peak and said at least one minor spectral peak.

16. A method for determining physiological data of a subject comprising:

a) generating at least one modulated light signal by modulating at least one light source at at least one predefined frequency, each said at least one modulated light signal having a different wavelength;

b) detecting a composite spectrophotometric light signal and converting said composite spectrophotometric light signal into an electrical signal, said composite spectrophotometric light signal being generated when a physiological signal of said subject is regulated by said at least one modulated light signal;

c) converting said electrical signal into a digital signal;

d) obtaining a frequency spectrum of said digital signal;

e) tracking at least one dominant spectral peak at said frequency spectrum, each said dominant spectral peak corresponding to each said at least one predefined frequency;

f) recognizing at least one minor spectral peak at said frequency spectrum from the vicinity of said at least one dominant spectral peak; and

g) determining said physiological data from said at least one dominant spectral peak and said at least one minor spectral peak.

17. The method of claim 16, wherein said step (a) comprises turning a first light source on and off at a first frequency to emit red light and turning a second light source on and off at a second frequency to emit infra-red light.

18. The method of claim 16, wherein said step (a) comprises rotating a wheel at a predetermined frequency so that said at least one light source being modulated at said at least one predefined frequency, said wheel being opaque to light and comprising at least one hollow coupled to a color filter for allowing light with certain wavelength to pass through, said predefined frequency being an integer multiple of said predetermined frequency.

19. The method of claim 16, wherein said step (a) comprises rotating a wheel at a predetermined frequency and keeping a static disc coupled to said wheel stationary for modulating said at least one light source;

said static disc comprising at least one color filter thereon which only allows light with certain wavelength to pass through;

said wheel comprising at least one hollow area in which said at least one color filter and said at least one hollow area align along an axis intermittently when said wheel rotates, said predefined frequency being an integer multiple of said predetermined frequency.

20. The method of claim 16 wherein said determining step further comprises the step of computing the average of a first minor spectral peak and a second minor spectral peak;

said first minor spectral peak being at the upper side band of said at least one dominant spectral peak and said second minor spectral peak being at the lower side band of said at least one dominant spectral peak.