COATED MEDICAL DEVICES INCLUDING A WATER-INSOLUBLE THERAPEUTIC AGENT
First Claim
Patent Images
1. A medical device, comprising:
- an implantable medical device structure having a surface; and
a coating layer carried by the surface and including;
(i) a water-insoluble therapeutic agent; and
(ii) one or more additives selected from heparin, heparan sulfate, dextran, and dextran sulfate; and
physiologically-acceptable salts thereof.
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Abstract
A medical device includes an implantable structure and a coating layer including a water-insoluble therapeutic agent and one or more additives selected from heparin, heparan sulfate, dextran and dextran sulfate, and physiologically-acceptable salts thereof. The one or more additives can be present in an amount effective to increase the rate of release of the water-insoluble therapeutic agent from the coating layer. The implantable medical device structure can be an expandable structure such as a balloon or stent. Also described are methods of making and using such implantable medical devices and coating layers.
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Citations
66 Claims
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1. A medical device, comprising:
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an implantable medical device structure having a surface; and a coating layer carried by the surface and including; (i) a water-insoluble therapeutic agent; and (ii) one or more additives selected from heparin, heparan sulfate, dextran, and dextran sulfate; and
physiologically-acceptable salts thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 58)
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21. A medical device, comprising:
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a catheter shaft; an inflatable balloon mounted on the catheter shaft; and a coating layer carried by the inflatable balloon and including; (i) a water-insoluble therapeutic agent; and (ii) one or more additives selected from heparin, heparan sulfate, dextran and dextran sulfate; and
physiologically-acceptable salts thereof. - View Dependent Claims (22, 23, 24)
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25. A medical device, comprising:
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an implantable medical device structure having a surface; and a coating layer carried by the surface and including; (i) paclitaxel or a macrolide immunosuppressive agent; and (ii) at least one additive selected from heparin, heparan sulfate, dextran, and dextran sulfate; and
physiologically-acceptable salts thereof. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. A method for manufacturing a medical device, comprising:
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applying a flowable medium comprising liquid, a water-insoluble therapeutic agent and one or more additives selected from heparin, heparan sulfate, dextran and dextran sulfate, and physiologically-acceptable salts thereof, to a surface of an implantable medical device structure or to a surface of a coating layer carried by the implantable medical device structure; and removing liquid from the medium to form a coating layer comprising the water-insoluble therapeutic agent and the one or more additives. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57)
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- 59. A coating layer including (i) a water-insoluble therapeutic agent and (ii) one or more additives selected from heparin, heparan sulfate, dextran and dextran sulfate, and physiologically acceptable salts thereof, for delivery of the water-insoluble therapeutic agent from an implantable medical device structure.
Specification