Azaindazoles useful as inhibitors of kinases

• US 20130310418A1
• Filed: 04/23/2013
• Published: 11/21/2013
• Est. Priority Date: 11/15/2006
• Status: Abandoned Application

• Current Assignee: Vertex Pharmaceuticals Incorporated
• Original Assignee: Vertex Pharmaceuticals Incorporated
• Inventors: Brenchley, Guy, Charrier, Jean-Damien, Durrant, Steven, Knegtel, Ronald, Ramaya, Sharn, Keily, Shazia, Cao, Jingrong
• Application Number:
  US13/868,123
• Publication Number:
  US 20130310418A1
• Time in Patent Office: Days
• US Class Current: 514/303
• CPC Class Codes: C07D 471/04 Ortho-condensed systems

Abstract

The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Claims

1. A compound of formula I

6. The compound according to claim 1, wherein Z² is a 4-8 membered heterocyclyl containing 1-2 heteroatoms selected from O, N, or S

7. The compound according to claim 1, wherein Z² is H or C_1-6aliphatic.

8. The compound according to claim 1, wherein n is 0.

9. The compound according to claim 1, wherein n is 1.

10. The compound according to claim 9, wherein L² is a C_1-6 alkylidene chain wherein up to two methylene units of the chain are optionally and independently replaced by —

N(R)—

, —

O—

, or —

S—

.

11. The compound according to claim 10, wherein L² is a C_1-3 alkylidene chain.

12. The compound according to claim 11, wherein L² is —

CH₂—

.

13. The compound according to claim 1, wherein R² is H.

16. The compound according to claim 1, wherein R⁵ is H, CN, NO₂, halo, or a C_1-6alkylidene chain.

18. The compound according to claims 16, wherein R⁵ is H.

28. A composition comprising a compound of claim 1, and a pharmaceutically acceptable carrier, adjuvant, or vehicle.

36. A process for preparing a compound of formula I:

37. The process of claim 36, further comprising the step of

a) reacting the compound of formula 4

38. The process of claim 37, further comprising cyclizing the compound of formula 3;

39. A process for preparing a compound of formula I:

2. (canceled)

3. (canceled)

4. (canceled)

5. (canceled)

14. (canceled)

15. (canceled)

17. (canceled)

19. (canceled)

20. (canceled)

21. (canceled)

22. (canceled)

23. (canceled)

24. (canceled)

25. (canceled)

26. (canceled)

27. A compound selected from the following:

29-35. -35. (canceled)