FOLDOVER SENSORS AND METHODS FOR MAKING AND USING THEM
First Claim
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1. An analyte sensor apparatus comprising:
- a base substrate comprising a planar sheet of a flexible material adapted to transition from a first configuration to a second configuration when the base substrate is folded to form a fixed bend;
a working electrode, a counter electrode and a reference electrode disposed upon a first surface of the base substrate;
a plurality of contact pads disposed upon the first surface of the base substrate;
a plurality of electrical conduits disposed upon the first surface of the base substrate, wherein the plurality of electrical conduits are adapted to transmit electrical signals between electrodes and contact pads separated by the fixed bend;
an analyte sensing layer disposed over the working electrode, wherein the analyte sensing layer detectably alters the electrical current at the working electrode in the presence of an analyte; and
an analyte modulating layer disposed over the analyte sensing layer, wherein the analyte modulating layer modulates the diffusion of analyte therethrough;
wherein;
the base substrate comprises the fixed bend so as to form an configuration characterized in that;
at least one electrode is disposed on a first side of the fixed bend; and
at least one electrode is disposed on a second side of the fixed bend.
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Abstract
The invention disclosed herein includes sensors having three dimensional configurations that allow expansive “360°” sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Embodiments of the invention provide analyte sensors having foldable substrates adapted to produce optimized configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.
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Citations
20 Claims
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1. An analyte sensor apparatus comprising:
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a base substrate comprising a planar sheet of a flexible material adapted to transition from a first configuration to a second configuration when the base substrate is folded to form a fixed bend; a working electrode, a counter electrode and a reference electrode disposed upon a first surface of the base substrate; a plurality of contact pads disposed upon the first surface of the base substrate; a plurality of electrical conduits disposed upon the first surface of the base substrate, wherein the plurality of electrical conduits are adapted to transmit electrical signals between electrodes and contact pads separated by the fixed bend; an analyte sensing layer disposed over the working electrode, wherein the analyte sensing layer detectably alters the electrical current at the working electrode in the presence of an analyte; and an analyte modulating layer disposed over the analyte sensing layer, wherein the analyte modulating layer modulates the diffusion of analyte therethrough; wherein; the base substrate comprises the fixed bend so as to form an configuration characterized in that; at least one electrode is disposed on a first side of the fixed bend; and at least one electrode is disposed on a second side of the fixed bend. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 19, 20)
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11. A method of making an analyte sensor apparatus, the method comprising the steps of:
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providing a base substrate formed from a planar sheet of a flexible material having a first surface and a second surface and adapted to transition from a first configuration to a second configuration when folded; forming a working electrode, a counter electrode and a reference electrode on the first surface of the base substrate; forming a plurality of contact pads on the first surface of the base substrate; forming a plurality of electrical conduits disposed upon the first surface of the base substrate, wherein the plurality of electrical conduits are adapted to transmit electrical signals between electrodes and contact pads separated by a fixed bend; forming an analyte sensing layer on the working electrode, wherein the analyte sensing layer detectably alters the electrical current at the working electrode in the presence of an analyte; forming an analyte modulating layer on the analyte sensing layer, wherein the analyte modulating layer modulates the diffusion of analyte therethrough; and folding the base substrate so as to introduce a fixed bend that results in a configuration characterized in that; at least one electrode is disposed on a first side of the fixed bend; and at least one electrode is disposed on a second side of the fixed bend; so that the analyte sensor apparatus is formed. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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Specification