BACTERIOPHAGES FOR REDUCING TOXICITY OF BACTERIA
First Claim
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1. A genetically modified bacteriophage comprising:
- (i) an exogenous polynucleotide which encodes an agent which reduces the toxicity of a bacterium, wherein said agent is non-toxic to the bacterium and does not affect directly the survival of said bacterium; and
(ii) an exogenous polynucleotide which encodes a selectable marker that renders the bacterium infected by the bacteriophage insensitive to a compound which is toxic to bacteria, wherein said selectable marker is not an antibiotic resistance gene.
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Abstract
A genetically modified bacteriophage is disclosed which comprises:
- (i) an exogenous polynucleotide which encodes an agent which reduces the toxicity of a bacterium; and
- (ii) an exogenous polynucleotide which encodes a selectable marker.
Uses thereof and kits comprising same are also disclosed.
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Citations
31 Claims
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1. A genetically modified bacteriophage comprising:
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(i) an exogenous polynucleotide which encodes an agent which reduces the toxicity of a bacterium, wherein said agent is non-toxic to the bacterium and does not affect directly the survival of said bacterium; and (ii) an exogenous polynucleotide which encodes a selectable marker that renders the bacterium infected by the bacteriophage insensitive to a compound which is toxic to bacteria, wherein said selectable marker is not an antibiotic resistance gene. - View Dependent Claims (2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 18, 20, 22, 24, 26, 28, 31)
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3. (canceled)
- 13. A genetically modified bacteriophage comprising an exogenous polynucleotide which encodes a polypeptide which reverses resistance of a bacterium to an antibiotic, wherein said polypeptide is 30S ribosomal subunit protein S12.
Specification