METHODS AND COMPOSITIONS SUITABLE FOR MANAGING BLOOD GLUCOSE IN ANIMALS

• US 20130316029A1
• Filed: 12/15/2011
• Published: 11/28/2013
• Est. Priority Date: 12/21/2010
• Status: Abandoned Application

• Current Assignee: Nestec SA (Nestle SA)
• Original Assignee: Nestec SA (Nestle SA)
• Inventors: Pan, Yuanlong, Middleton, Rondo Paul, Hannah, Steven Scott
• Application Number:
  US13/996,245
• Publication Number:
  US 20130316029A1
• Time in Patent Office: Days
• US Class Current: 424/766
• CPC Class Codes: A23K 20/10 Organic substances
• CPC Class Codes: A23K 20/105 Aliphatic or alicyclic compounds
• CPC Class Codes: A23K 20/111 Aromatic compounds
• CPC Class Codes: A23K 20/142 Amino acids; Derivatives thereof
• CPC Class Codes: A23K 20/158 Fatty acids; Fats; Products containing oils or fats
• CPC Class Codes: A23K 20/174 Vitamins
• CPC Class Codes: A23K 50/40 for carnivorous animals, e.g. cats or dogs
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23L 33/105 Plant extracts, their artificial duplicates or their derivatives
• CPC Class Codes: A23L 33/115 Fatty acids or derivatives thereof; Fats or oils
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/15 Vitamins
• CPC Class Codes: A23L 33/16 Inorganic salts, minerals or trace elements
• CPC Class Codes: A23L 33/175 Amino acids
• CPC Class Codes: A23L 5/44 using carotenoids or xanthophylls
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/015 carbocyclic
• CPC Class Codes: A61K 31/047 having two or more hydroxy groups, e.g. sorbitol
• CPC Class Codes: A61K 31/07 Retinol compounds, e.g. vitamin A retinoic acids A61K31/203
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/353 : 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• CPC Class Codes: A61K 31/355 : Tocopherols, e.g. vitamin E
• CPC Class Codes: A61K 31/375 : Ascorbic acid, i.e. vitamin C; Salts thereof
• CPC Class Codes: A61K 31/555 : containing heavy metals, e.g. hemin, hematin, melarsoprol
• CPC Class Codes: A61K 33/04 : Sulfur, selenium or tellurium; Compounds thereof
• CPC Class Codes: A61K 33/30 : Zinc; Compounds thereof
• CPC Class Codes: A61K 36/18 : Magnoliophyta (angiosperms)
• CPC Class Codes: A61K 36/87 : Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
• CPC Class Codes: A61K 38/05 : Dipeptides
• CPC Class Codes: A61K 45/06 : Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/04 : Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/08 : for glucose homeostasis pancreatic hormones A61P5/48
• CPC Class Codes: A61P 3/10 : for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 39/06 : Free radical scavengers or antioxidants
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/50 : for increasing or potentiating the activity of insulin

Abstract

The invention provides methods, compositions, and dietary formulations useful for managing blood glucose, preventing or treating insulin resistance, and improving insulin sensitivity. The methods comprise administering to an animal a therapeutically effective amount of a combination of at least two of one or more antioxidants; one or more anti-glycation agents; one or more body fat reducing agents; one or more insulin sensitivity enhancing agents; and one or more anti-inflammatory agents.

Claims

1. A method for managing blood glucose in an animal comprising administering to the animal a therapeutically effective amount of a combination of at least two of one or more antioxidants;

one or more anti-glycation agents;

one or more body fat reducing agents, one or more insulin sensitivity enhancing agents; and

one or more anti-inflammatory agents.

5. The method of claim 1 wherein the antioxidants are selected from the group consisting of vitamin C, polyphenols, proanthocyanidins, anthocyanins, bioflavonoids, selenium, alpha-lipoic acid, glutathione, catechin, epicatechin, epigallocatechin, epigallocatechin gallate, epicatechin gallate, cysteine, vitamin E, gamma tocopherol, alpha-carotene, beta-carotene, lutein, zeaxanthin, retinal, astaxanthin, cryptoxanthin, lycopene and resveratrol.

7. The method of claim 1 wherein the antioxidants are administered to the animal in amounts of from about 0.001 to about 1000 mg/kg/day.

9. The method of claim 1 wherein the anti-glycation agents are selected from the group consisting of carnosine, benfotiamine, pyridoxamine, alpha-lipoic acid, phenacyldimethyithiazolium chloride, taurine, aminoguanidine, resveratrol, and aspirin.

11. The method of claim 1 wherein the anti-glycation agents are administered to the animal in amounts of from about 0.01 to about 1000 mg/kg/day.

13. The method of claim 1 wherein the body fat reducing agents are selected from the group consisting of conjugated linoleic acid (CLA), carnitine, acetyl-carnitine, pyruvate, polyunsaturated fatty acids, medium chain fatty acids, medium chain triglycerides, and soy isoflavones.

15. The method of claim 1 wherein the body fat reducing agents are administered to the animal in amounts of from about 0.001 to about 1000 mg/kg/day.

17. The method of claim 1 wherein the insulin sensitivity enhancing agents are selected from the group consisting of chromium, chromium picolinate, cinnamon, cinnamon extract, polyphenols from cinnamon and witch hazel, coffee berry extract, chlorogenic acid, caffeic acid, a source of zinc, and grape seed extract.

19. The method of claim 1 wherein the insulin sensitivity enhancing agents are administered to the animal in amounts of from about 0.001 to about 1000 mg/kg/day.

21. The method of claim 1 wherein the anti-inflammatory agents are selected from the group consisting of omega-3 fatty acids and curcumin.

22. The method of claim 21 wherein the omega-3 fatty acids are selected from the group consisting of α

-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid, flax seed, flax oil, walnuts, canola oil, wheat germ, and fish oil.

23. The method of claim 21 where the source of curcumin is selected from the group consisting of (1,7-bis(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione;

1-(4-hydroxyphenyl-7-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione;

1,7-bis-(4-hydroxyphenyl()-hepta-1,6-diene-3,5-dione), demethoxycurcumin, and bisdemethoxycurcumin.

24. The method of claim 1 wherein the anti-inflammatory agents are administered to the animal in amounts of from about 0.001 to about 1000 mg/kg/day.

26. The method of claim 1 wherein the dietary formulation comprises vitamin E, vitamin C, alpha-carotene, beta-carotene, lutein, zeaxanthin, cryptoxanthin, selenium, lycopene, chromium, grape seed extract, zinc, CLA, carnitine, acetyl-carnitine, and carnosine.

27. The method of claim 1 wherein the dietary formulation comprises vitamin E, vitamin C, alpha-carotene, beta-carotene, lutein, zeaxanthin, cryptoxanthin, selenium, lycopene, chromium, grape seed extract, zinc, CLA, carnitine, acetyl-carnitine, carnosine, fish oil, and curcumin.

28. The method of claim 1 wherein the dietary formulation comprises vitamin E, vitamin C, alpha-carotene, beta-carotene, lutein, zeaxanthin, cryptoxanthin, selenium, lycopene, fish oil, and curcumin.

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85. A dietary formulation suitable for man aging blood glucose, preventing or treating insulin resistance, and improving insulin sensitivity in an animal comprising a combination of at least two of:

one or more antioxidants, one or more anti-glycation agents;

one or more body fat reducing agents;

one or more insulin sensitivity enhancing agents; and

one or more anti-inflammatory agents.

89. The dietary formulation of claim 85 wherein the antioxidants are selected from the group consisting of vitamin C, polyphenols, proanthocyanidins, anthocyanins, bioflavonoids, selenium, alpha-lipoic acid, glutathione, catechin, epicatechin, epigallocatechin, epigallocatechin gallate, epicatechin gallate, cysteine vitamin E, gamma tocopherol, alpha-carotene, beta-carotene, lutein, zeaxanthin, retinal, astaxanthin cryptoxanthin, lycopene and resveratrol.

93. The dietary formulation of claim 85 wherein the anti-glycation agents are selected from the group consisting of carnosine, benfotiamine, pyridoxamine, alpha-lipoic acid, phenacyldimethyithiazolium chloride, taurine. aminoguanidine, resveratrol, and aspirin.

97. The dietary formulation of claim 85 wherein the body fat reducing agents are selected from the group consisting of conjugated linoleic acid (CLA), carnitine, acetyl-carnitine, pyruvate, polyunsaturated fatty acids, medium chain fatty acids, medium chain triglycerides, and soy isoflavones.

101. The dietary formulation of claim 85 wherein the insulin sensitivity enhancing agents are selected from the group consisting of chromium, chromium picolinate, cinnamon, cinnamon extract, polyphenols from cinnamon and witch hazel, coffee berry extract, chlorogenic acid, caffeic acid, a source of zinc, and grape seed extract.

105. The dietary formulation of claim 85 wherein the anti -inflammatory agent are selected from the group consisting of omega-3 fatty acids and curcumin.

106. The dietary formulation of claim 85 wherein the omega-3 fatty acids are selected from the group consisting of α

-linolenic acid eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid, flax seed, flax oil, walnuts, canola oil, wheat germ, and fish oil.

107. The dietary formulation of claim 105 where the source of curcumin is selected from the group consisting of (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione;

1-(4-hydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione;

1,7-bis-(4-hydroxyphenyl)-hepta-1,6-diene-3,5-dione), demethoxycurcumin, and bisdemethoxycurcumin.

110. The dietary formulation of claim 85 wherein the dietary formulation comprises vitamin E, vitamin C, alpha-carotene, beta-carotene, lutein, zeaxanthin, cryptoxanthin, selenium, lycopene, chromium, grape seed extract, zinc, CLA, carnitine, acetyl-carnitine, and carnosine.

111. The dietary formulation of claim 85 wherein the dietary formulation comprises vitamin E, vitamin C, alpha-carotene, beta-carotene, lutein, zeaxanthin, cryptoxanthin, selenium, lycopene, chromium, grape seed extract, zinc, CLA, carnitine, acetyl-carnitine, carnosine, fish oil, and curcumin.

112. The dietary formulation of claim 85 wherein the dietary formulation comprises vitamin E, vitamin C, alpha-carotene, beta-carotene, lutein, zeaxanthin, cryptoxanthin, selenium, lycopene, fish oil, and curcumin.

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