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TARGET ENRICHMENT AND LABELING FOR MULTI-KILOBASE DNA

  • US 20130323725A1
  • Filed: 03/14/2013
  • Published: 12/05/2013
  • Est. Priority Date: 06/01/2012
  • Status: Active Grant
First Claim
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1. A method comprising:

  • a) clamping the top and bottom strands of a double stranded DNA molecule to produce a duplex in which the top and bottom strands are linked;

    b) denaturing the duplex to produce a denatured product; and

    c) renaturing the denatured product in the presence of a labeled oligonucleotide that is complementary to a sequence of nucleotides in the double stranded DNA molecule, thereby producing a D-loop-containing product.

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