Method for Estimating Pressure Gradients and Fractional Flow Reserve from Computed Tomography Angiography: Transluminal Attenuation Flow Encoding

• US 20130324842A1
• Filed: 04/23/2013
• Published: 12/05/2013
• Est. Priority Date: 05/29/2012
• Status: Abandoned Application

• Current Assignee: Johns Hopkins University
• Original Assignee: Johns Hopkins University
• Inventors: Lardo, Albert C., Mittal, Rajat, Seo, Jung Hee, Eslami, Parastou
• Application Number:
  US13/868,665
• Publication Number:
  US 20130324842A1
• Time in Patent Office: Days
• US Class Current: 600/426
• CPC Class Codes: A61B 6/03 Computed tomography [CT] echo-tomography A61B8/14
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61B 6/503 for diagnosis of the heart
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography
• CPC Class Codes: A61B 6/507 for determination of haemodynamic parameters, e.g. perfusion CT
• CPC Class Codes: A61B 6/5217 extracting a diagnostic or physiological parameter from medical diagnostic data
• CPC Class Codes: A61B 6/56 Details of data transmission or power supply, e.g. use of slip rings
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment

Abstract

An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transarterial attenuation gradient for the coronary artery of the patient. The patient specific transarterial attenuation gradient is compared to previously collected data to determine an estimate of a pressure gradient and/or fractional flow reserve (FFR) for the patient. As more data is collected, the data can be added to the database in order to increase the accuracy of future assessments. The database can also be enhanced by adding data generated by canonical models and mathematical analysis.

Claims

1. A method for determining a functional significance of coronary artery stenosis comprising:

gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient;

using the patient-specific data to calculate a patient-specific transarterial attenuation gradient for the coronary artery of the patient; and

comparing the patient specific transarterial attenuation gradient to previously collected data to determine an estimate of a pressure gradient for the patient.

2. The method of claim 1 further comprising executing the method using a computer readable medium.

3. The method of claim 1 further comprising performing a cardiac computed tomography scan to gather the patient specific data.

4. The method of claim 1 further comprising creating a database of the previously collected data.

5. The method of claim 4 further comprising adding the patient specific data and patient specific transarterial gradient to the database.

6. The method of claim 4 further comprising building the database using information chosen from at least one of the group of patient data, arterial model data, and analysis based data.

7. The method of claim 1 further comprising generating at least one of a graphical view, tabular representation, or curve-fit equation of the previously collected data for comparison to the patient specific transarterial gradient.

8. The method of claim 1 further comprising analyzing asymmetric constrictions.

9. The method of claim 1 further comprising analyzing symmetric constrictions.

10. The method of claim 1 wherein the patient-specific data is represented as at least one of a graph, a table, or a curve-fit equation of concentration of the contrast agent over a distance in the coronary artery.

11. A system for determining a functional significance of coronary artery stenosis comprising:

a computing device further comprising a computer readable medium programmed for;

gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient;

using the patient-specific data to calculate a patient-specific transarterial attenuation gradient for the coronary artery of the patient; and

comparing the patient specific transarterial attenuation gradient to previously collected data to determine an estimate of a pressure gradient for the patient.

12. The system of claim 11 wherein the patient-specific data comprises computed tomography scan data.

13. The system of claim 11 further comprising a computed tomography scanning device.

14. The system of claim 13 wherein the computed tomography scanning device is networked wirelessly or in a wired manner to the computing device.

15. The system of claim 11 further comprising creating a database of the previously collected data.

16. The system of claim 15 further comprising adding the patient specific data and patient specific transarterial gradient to the database.

17. The system of claim 15 further comprising building the database using information chosen from at least one of the group of patient data, arterial model data, and analysis based data.

18. The system of claim 15 further comprising storing the database on the computing device.

19. The system of claim 11 further comprising generating at least one of a graphical view, tabular representation, or curve-fit equation of the previously collected data for comparison to the patient specific transarterial gradient.

20. The system of claim 11 wherein the patient-specific data is represented as at least one of a graph, a table, or a curve-fit equation of concentration of the contrast agent over a distance in the coronary artery.