METHOD FOR ENABLING THE PLANNING OF A TREATMENT OF A TUMOUR USING A THERAPEUTIC VIRUS
First Claim
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1. A method for planning of a treatment of a tumour within a body using a therapeutic virus, comprising the steps of generating a tumour cell density map representing the tumour cell density in a plurality of respective cubic volumes into which a body part is divided, wherein the body part comprises at least a part of the tumour;
- generating a virus concentration map which represents an initial virus distribution of the therapeutic virus in at least the body part;
aligning the virus concentration map with the tumour cell density map;
simulating the virus replication by calculating the number of generated viruses in each volume of the body part;
simulating the propagation of the viruses within the body part by determining the volumes of the body part into which the viruses within a particular volume spread;
updating the virus concentration map and the tumour cell density map;
calculating whether or not the therapeutic virus has spread throughout the tumour; and
returning to the step of simulating the virus replication if this is not the case.
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Abstract
A method for enabling the planning of a treatment of a tumour within a body using a therapeutic virus, wherein the virus distribution in the body is calculated by simulating the virus replication process, starting from an initial virus distribution, and the calculated virus distribution is provided for the planning.
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Citations
13 Claims
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1. A method for planning of a treatment of a tumour within a body using a therapeutic virus, comprising the steps of generating a tumour cell density map representing the tumour cell density in a plurality of respective cubic volumes into which a body part is divided, wherein the body part comprises at least a part of the tumour;
- generating a virus concentration map which represents an initial virus distribution of the therapeutic virus in at least the body part;
aligning the virus concentration map with the tumour cell density map;
simulating the virus replication by calculating the number of generated viruses in each volume of the body part;
simulating the propagation of the viruses within the body part by determining the volumes of the body part into which the viruses within a particular volume spread;
updating the virus concentration map and the tumour cell density map;
calculating whether or not the therapeutic virus has spread throughout the tumour; and
returning to the step of simulating the virus replication if this is not the case. - View Dependent Claims (2, 5, 6, 7, 8, 9, 10, 11, 12, 13)
- generating a virus concentration map which represents an initial virus distribution of the therapeutic virus in at least the body part;
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3. (canceled)
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4. (canceled)
Specification