HIGH RESOLUTION HIGH CONTRAST MRI FOR FLOWING MEDIA

• US 20130328560A1
• Filed: 10/16/2012
• Published: 12/12/2013
• Est. Priority Date: 06/06/2012
• Status: Active Grant

• Current Assignee: Aspect Imaging Ltd.
• Original Assignee: Aspect Imaging Ltd.
• Inventors: RAPOPORT, Uri
• Granted Patent: US 9,182,462 B2
• Time in Patent Office: Days
• US Class Current: 324/309
• CPC Class Codes: G01N 24/084 Detection of potentially hazardous samples, e.g. toxic samples, explosives, drugs, firearms, weapons
• CPC Class Codes: G01R 33/32 Excitation or detection systems, e.g. using radio frequency signals
• CPC Class Codes: G01R 33/445 MR involving a non-standard magnetic field B0, e.g. of low magnitude as in the earth's magnetic field or in nanoTesla spectroscopy, comprising a polarizing magnetic field for pre-polarisation, B0 with a temporal variation of its magnitude or direction such as field cycling of B0 or rotation of the direction of B0, or spatially inhomogeneous B0 like in fringe-field MR or in stray-field imaging
• CPC Class Codes: G01R 33/56 Image enhancement or correction, e.g. subtraction or averaging techniques , e.g. improvement of signal-to-noise ratio and resolution

Abstract

An MRI device for providing high-contrast, high-resolution images of a fluid. The device includes: an envelope for at least partially confining the fluid; a plurality of magnets located at least partially around the envelope; and a CPU to process the images, including a computer readable medium containing instructions for generating at least one third image superimposing at least one image of the first images with at least one image of the second images, whereby a high-contrast, high-resolution real-time continuous images of the fluid is obtained.

Claims

1. An MRI-based system for providing high-contrast high-resolution images of a fluid comprising:

a. an MRI device for providing high contrast high resolution images of a fluid, comprising;

i. an envelope for least partially confining said fluid;

ii. a plurality of magnets located at least partially around said envelope, said assembly comprising;

a. a least one first magnet configured to provide a high magnetic field for generating multiple time-resolved one or more first images at high resolution of at least a portion of said fluid; and

b. a least one second magnet configured to provide a low magnetic field for generating multiple time-resolved one or more second images at high contrast of at least portion of same said fluid;

wherein at least one image of said first images and at least one image of said second images being generated in a time no greater than approximately the time between two first images; and

iii. a CPU to process said images comprising a computer readable medium containing instructions for generating at least one third image superimposing at least one image of said first images with at least one image of said second images, whereby a high-contrast, high-resolution real-time continuous image of said fluid is obtained and

b. a fluid processing unit operation;

wherein the operation provided by said fluid processing unit operation is continuously online feedbacked by means of said MRI device.

2. The MRI-based system of claim 1, wherein said fluid processing unit operation is one of a group consisting of mixing, kneading, transporting, analyzing, reacting, cooking, freezing, controlling the temperature, controlling the pressure, emulsifying, de-emulsifying, gelation, de-gelation, liquidizing, polymerizing, de-polymerizing, controlling viscosity, controlling density, controlling particulate concentration, controlling particulate size, controlling particulate density, creating a suspension, clearing a suspension from the fluid, assessing contaminant levels, clearing contaminants, and any combination thereof.

3. The MRI-based system of claim I, wherein said feedbacking comprises one of a group consisting of altering temperature, altering pressure, altering volume, altering mixing speed, altering mixing time, altering flow rate, altering composition of at least one component of the fluid, altering particulate size, altering particulate density, altering levels of electromagnetic radiation, altering wavelengths of electromagnetic radiation, altering degree of filtration, altering method of filtration, adding filters, removing filters, changing filters, starting at least some portion of the fluid processing unit operation, stopping at least some portion of the fluid processing unit operation, and any combination thereof.

4. An MRI based method for integrating analysis and production of a product, at least one step of said production comprising a fluid processing, comprising:

a. providing an MRI device for providing high contrast high resolution images of a fluid, comprising;

i. an envelope for least partially confining said fluid;

ii. a plurality of magnets located at least partially around said envelope, said assembly comprising;

a. a least one first magnet configured to provide a high magnetic field for generating multiple time-resolved one or more first images at high resolution of at least a portion of said fluid; and

b. a least one second magnet configured to provide a low magnetic field for generating multiple time-resolved one or more second images at high contrast of at least portion of same said fluid;

wherein at least one image of said first images and at least one image of said second images being generated in a time no greater than approximately the time between two first images; and

iii. a CPU to process said images comprising a computer readable medium containing instructions for generating at least one third image superimposing at least one image of said first images with at least one image of said second images, whereby a high-contrast, high-resolution real-time continuous image of said fluid is obtained;

a. providing a fluid processing unit operation;

b. operating said fluid processing unit operation;

c. continuously generating said first at least one images, said second at least one images and said third superimposed at least one images, such that a high-contrast, high resolution real-time continuous image of said fluid is obtained

d. analyzing said images of fluid operated on by said fluid processing unit operation generated by said MRI device, whereby a high-contrast, high resolution real-time continuous image of said fluid is obtained; and

e. feedbacking the results of said analysis to said fluid processing unit

wherein the operation provided by said fluid processing unit operation is continuously online feedbacked by means of said MRI device.

5. The MRI-based method of claim 4, additionally comprising a step of selecting said fluid processing unit operation from a group consisting of mixing, kneading, transporting, analyzing, reacting, cooking, freezing, controlling the temperature, controlling the pressure, emulsifying, de-emulsifying, gelation, de-gelation, liquidizing, polymerizing, de-polymerizing, controlling viscosity, controlling density, controlling particulate concentration, controlling particulate size, controlling particulate density, creating a suspension, clearing a suspension from the fluid, assessing contaminant levels, clearing contaminants, and any combination thereof.

6. The MRI-based method of claim 4, additionally comprising a step of selecting said feedbacking from of a group consisting of altering temperature, altering pressure, altering volume, altering mixing speed, altering mixing time, altering flow rate, altering composition of at least one component of the fluid, altering particulate size, altering particulate density, altering levels of electromagnetic radiation, altering wavelengths of electromagnetic radiation, altering degree of filtration, altering method of filtration, adding filters, removing filters, changing filters, starting at least some portion of the fluid processing unit operation, stopping at least some portion of the fluid processing unit operation, and any combination thereof.

7. An MRI-based system for screening for the presence of hazardous biological or chemical agent residues carried by an individual, comprising

a. an MRI device for providing high contrast high resolution images of a fluid, comprising:

i. an envelope for least partially confining said fluid;

ii. a plurality of magnets located at least partially around said envelope, said assembly comprising;

a. a least one first magnet configured to provide a high magnetic field for generating multiple time-resolved one or more first images at high resolution of at least a portion of said fluid; and

b. a least one second magnet configured to provide a low magnetic field for generating multiple time-resolved one or more second images at high contrast of at least portion of same said fluid;

wherein at least one image of said first images and at least one image of said second images being generated in a time no greater than approximately the time between two first images; and

iii. a CPU to process said images comprising a computer readable medium containing instructions for generating at least one third image superimposing at least one image of said first images with at least one image of said second images, whereby a high-contrast, high-resolution real-time continuous image of said fluid is obtained

b. a fluid inlet in physical connection with said envelope;

c. a fluid streamer for streaming a fluid over an individual passing through said fluid stream;

d. a separator for separating out particles carried downstream by said fluid stream; and

e. a particle collector for collecting said particles to provide a continuous fluid facilitated flow within said inlet to said envelope

whereby a high-contrast, high resolution real-time continuous image of said fluid is obtained and the presence of said hazardous biological or chemical agent residues is indicated.

8. The MRI-based system of claim 7, wherein the type of hazardous biological or chemical agent residues carried by said individual is indicated.

9. The MRI-based system of claim 7, wherein said fluid stream is an air curtain.

10. The MRI-based system according to claim 7, wherein said separating is facilitated by means of a cyclone or filter or both.

11. The MRI-based system according to claim 7, wherein said collecting of said particles is facilitated by a particle collecting means selected from a group comprising activated carbon, a filter including air filter, water filter, paper filter, HEPA filter, microfilter, water filter, water curtain, other conventional filter, other collection device, and any combination thereof.

12. An MRI-based method for screening for the presence of hazardous biological or chemical agent residues carried by an individual, comprising

a. providing an MRI device for providing high contrast high resolution images of a fluid, comprising:

i. an envelope for least partially confining said fluid;

ii. a plurality of magnets located at least partially around said envelope, said assembly comprising;

a. a least one first magnet configured to provide a high magnetic field for generating multiple time-resolved one or more first images at high resolution of at least a portion of said fluid; and

b. a least one second magnet configured to provide a low magnetic field for generating multiple time-resolved one or more second images at high contrast of at least portion of same said fluid;

wherein at least one image of said first images and at least one image of said second images being generated in a time no greater than approximately the time between two first images; and

iii. a CPU to process said images comprising a computer readable medium containing instructions for generating at least one third image superimposing at least one image of said first images with at least one image of said second images, whereby a high-contrast, high-resolution real-time continuous image of said fluid is obtained;

a. providing said MRI with a fluid inlet in physical connection with said envelope;

b. providing a fluid stream for said individual to pass through;

c. streaming fluid over said individual passing through said fluid stream;

d. separating out particles carried downstream by said fluid stream;

e. collecting said particles by a particle collecting means to provide a continuous fluid facilitated flow within said inlet to said envelope; and

f. continuously generating first at least one images, second at least one images and third superimposed at least one images, such that a high-contrast, high resolution real-time continuous image of said fluid is obtained

whereby the presence of said hazardous biological or chemical agent residues is indicated.

13. The MRI-based method of claim 12, comprising an additional step of indicating the type of hazardous biological or chemical agent residues carried by said individual.

14. The MRI-based method of claim 12, comprising an additional step of selecting said fluid stream to be an air curtain.

15. The MRI-based method of claim 12, comprising an additional step of facilitating said step of separating by means of a cyclone or filter or both.

16. The MRI-based method of claim 12, comprising an additional step of facilitating said step of collecting said particles by a particle collecting means selected from a group comprising activated carbon, a filter including air filter, water filter, paper filter, HEPA filter, microfilter, water filter, water curtain, other conventional filter, other collection device, and any combination thereof.

17. An MRI-based system for rapidly screening for the presence of hazardous biological or chemical residue in a flowing main fluid, comprising:

a. an MRI device for providing high contrast high resolution images of a fluid, comprising;

i. an envelope for least partially confining said fluid;

ii. a plurality of magnets located at least partially around said envelope, said assembly comprising;

a. a least one first magnet configured to provide a high magnetic field for generating multiple time-resolved one or more first images at high resolution of at least a portion of said fluid; and

b. a least one second magnet configured to provide a low magnetic field for generating multiple time-resolved one or more second images at high contrast of at least portion of same said fluid;

wherein at least one image of said first images and at least one image of said second images being generated in a time no greater than approximately the time between two first images; and

iii. a CPU to process said images comprising a computer readable medium containing instructions for generating at least one third image superimposing at least one image of said first images with at least one image of said second images, whereby a high-contrast, high-resolution real-time continuous image of said fluid is obtained;

a. a main fluid;

b. a purging device to separate an analyzable-size sample of fluid from said main fluid, said separator fluidly connected to said envelope;

c. Functionalized Paramagnetic Particles (FPP) with a paramagnetic core and a moiety configured to interact with said biological or chemical agent residues;

d. means for mixing said FPP with said analyzable-size sample of fluid; and

e. a facilitator to facilitate flow of said fluid mixed with said FPP through said MRI device;

whereby a high-contrast, high-resolution real-time continuous image of said at least one analyzable-size sample of said fluid is obtained, and further whereby the presence of said hazardous biological or chemical agent residues in said main fluid is indicated.

18. The MRI-based system according to claim 17, wherein said step of separating is facilitated by means of a cyclone or filter or both.

19. The MRI-based system according to claim 17, wherein said step of collecting said particles is facilitated by a particle collecting means selected from a group comprising activated carbon, a filter including air filter, water filter, paper filter, HEPA filter, microfilter, water filter, water curtain, other conventional filter, other collection device, and any combination thereof.

20. The MRI-based system of claim 17, wherein the type of hazardous biological or chemical agent residues in said main fluid is indicated.

21. The MRI-based system of claim 17, wherein the fluid is one of a group consisting of potable water, sewage, irrigation water, sea water, river water, lake water, industrial effluent, farm effluent, effluent from human habitation, road runoff, blood, lymph, a beverage, cleaning fluid, and any combination thereof.

22. An MRI-based method for rapidly screening for the presence of hazardous biological or chemical residue in a flowing main fluid, comprising

a. providing an MRI device for providing high contrast high resolution images of a fluid, comprising:

i. an envelope for least partially confining said fluid;

ii. a plurality of magnets located at least partially around said envelope, said assembly comprising;

a. a least one first magnet configured to provide a high magnetic field for generating multiple time-resolved one or more first images at high resolution of at least a portion of said fluid; and

b. a least one second magnet configured to provide a low magnetic field for generating multiple time-resolved one or more second images at high contrast of at least portion of same said fluid;

wherein at least one image of said first images and at least one image of said second images being generated in a time no greater than approximately the time between two first images; and

iii. a CPU to process said images comprising a computer readable medium containing instructions for generating at least one third image superimposing at least one image of said first images with at least one image of said second images, whereby a high-contrast, high-resolution real-time continuous image of said fluid is obtained;

b. purging said main fluid to an analyzable-size sample;

c. facilitatedly flowing said purged fluid through said MRI;

d. providing Functionalized Paramagnetic Particles (FPP) with a paramagnetic core and a moiety configured to interact with said biological or chemical agent residues;

e. introducing said FPP with said purged fluid,

f. if said hazardous biological or chemical residue is present in said purged fluid, then interacting said FPP with said biological or chemical agent residues;

g. generating multiple time resolved one or more first images at high resolution of at least a portion of said purged fluid;

h. generating multiple time resolved one or more second images at high contrast of at least portion of same said purged fluid;

i. superimposing at least one image of said first images with at least one image of said second images whereby a high-contrast, high resolution real-time continuous image of said purged fluid is obtained; and

j. measuring a change in a nuclear relaxation property of said purged fluid caused by said interaction between said FPP and said biological or chemical agent residues in the applied magnetic field, as indicated by said high-contrast, high resolution real-time continuous image of said purged fluid; and

k. correlating said change to the presence of said biological or chemical agent residues in said purged fluid,

whereby the presence of said hazardous biological or chemical agent residues in said main fluid is indicated.

23. The MRI-based method according to claim 22, additionally comprising a step of facilitating said step of separating by means of a cyclone or filter or both.

24. The MRI-based method according to claim 22, additionally comprising a step of facilitating said step of collecting said particles by a particle collecting means selected from a group comprising activated carbon, a filter including air filter, water filter, paper filter, HEPA filter, microfilter, water filter, water curtain, other conventional filter, other collection device, and any combination thereof.

25. The MRI-based method of claim 22, additionally comprising a step of indicating the type of hazardous biological or chemical agent residues in said main fluid.

26. The MRI-based method of claim 22, additionally comprising a step of selecting the fluid from a group consisting of potable water, sewage, irrigation water, sea water, river water, lake water, industrial effluent, farm effluent, effluent from human habitation, road runoff, blood, lymph, a beverage, cleaning fluid, and any combination thereof.