HIGH RESOLUTION HIGH CONTRAST MRI FOR FLOWING MEDIA
First Claim
Patent Images
1. An MRI-based system for providing high-contrast high-resolution images of a fluid comprising:
- a. an MRI device for providing high contrast high resolution images of a fluid, comprising;
i. an envelope for least partially confining said fluid;
ii. a plurality of magnets located at least partially around said envelope, said assembly comprising;
a. a least one first magnet configured to provide a high magnetic field for generating multiple time-resolved one or more first images at high resolution of at least a portion of said fluid; and
b. a least one second magnet configured to provide a low magnetic field for generating multiple time-resolved one or more second images at high contrast of at least portion of same said fluid;
wherein at least one image of said first images and at least one image of said second images being generated in a time no greater than approximately the time between two first images; and
iii. a CPU to process said images comprising a computer readable medium containing instructions for generating at least one third image superimposing at least one image of said first images with at least one image of said second images, whereby a high-contrast, high-resolution real-time continuous image of said fluid is obtained andb. a fluid processing unit operation;
wherein the operation provided by said fluid processing unit operation is continuously online feedbacked by means of said MRI device.
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Abstract
An MRI device for providing high-contrast, high-resolution images of a fluid. The device includes: an envelope for at least partially confining the fluid; a plurality of magnets located at least partially around the envelope; and a CPU to process the images, including a computer readable medium containing instructions for generating at least one third image superimposing at least one image of the first images with at least one image of the second images, whereby a high-contrast, high-resolution real-time continuous images of the fluid is obtained.
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Citations
26 Claims
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1. An MRI-based system for providing high-contrast high-resolution images of a fluid comprising:
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a. an MRI device for providing high contrast high resolution images of a fluid, comprising; i. an envelope for least partially confining said fluid; ii. a plurality of magnets located at least partially around said envelope, said assembly comprising; a. a least one first magnet configured to provide a high magnetic field for generating multiple time-resolved one or more first images at high resolution of at least a portion of said fluid; and b. a least one second magnet configured to provide a low magnetic field for generating multiple time-resolved one or more second images at high contrast of at least portion of same said fluid;
wherein at least one image of said first images and at least one image of said second images being generated in a time no greater than approximately the time between two first images; andiii. a CPU to process said images comprising a computer readable medium containing instructions for generating at least one third image superimposing at least one image of said first images with at least one image of said second images, whereby a high-contrast, high-resolution real-time continuous image of said fluid is obtained and b. a fluid processing unit operation; wherein the operation provided by said fluid processing unit operation is continuously online feedbacked by means of said MRI device. - View Dependent Claims (2)
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3. The MRI-based system of claim I, wherein said feedbacking comprises one of a group consisting of altering temperature, altering pressure, altering volume, altering mixing speed, altering mixing time, altering flow rate, altering composition of at least one component of the fluid, altering particulate size, altering particulate density, altering levels of electromagnetic radiation, altering wavelengths of electromagnetic radiation, altering degree of filtration, altering method of filtration, adding filters, removing filters, changing filters, starting at least some portion of the fluid processing unit operation, stopping at least some portion of the fluid processing unit operation, and any combination thereof.
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4. An MRI based method for integrating analysis and production of a product, at least one step of said production comprising a fluid processing, comprising:
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a. providing an MRI device for providing high contrast high resolution images of a fluid, comprising; i. an envelope for least partially confining said fluid; ii. a plurality of magnets located at least partially around said envelope, said assembly comprising; a. a least one first magnet configured to provide a high magnetic field for generating multiple time-resolved one or more first images at high resolution of at least a portion of said fluid; and b. a least one second magnet configured to provide a low magnetic field for generating multiple time-resolved one or more second images at high contrast of at least portion of same said fluid;
wherein at least one image of said first images and at least one image of said second images being generated in a time no greater than approximately the time between two first images; andiii. a CPU to process said images comprising a computer readable medium containing instructions for generating at least one third image superimposing at least one image of said first images with at least one image of said second images, whereby a high-contrast, high-resolution real-time continuous image of said fluid is obtained; a. providing a fluid processing unit operation; b. operating said fluid processing unit operation; c. continuously generating said first at least one images, said second at least one images and said third superimposed at least one images, such that a high-contrast, high resolution real-time continuous image of said fluid is obtained d. analyzing said images of fluid operated on by said fluid processing unit operation generated by said MRI device, whereby a high-contrast, high resolution real-time continuous image of said fluid is obtained; and e. feedbacking the results of said analysis to said fluid processing unit wherein the operation provided by said fluid processing unit operation is continuously online feedbacked by means of said MRI device. - View Dependent Claims (5, 6)
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7. An MRI-based system for screening for the presence of hazardous biological or chemical agent residues carried by an individual, comprising
a. an MRI device for providing high contrast high resolution images of a fluid, comprising: -
i. an envelope for least partially confining said fluid; ii. a plurality of magnets located at least partially around said envelope, said assembly comprising; a. a least one first magnet configured to provide a high magnetic field for generating multiple time-resolved one or more first images at high resolution of at least a portion of said fluid; and b. a least one second magnet configured to provide a low magnetic field for generating multiple time-resolved one or more second images at high contrast of at least portion of same said fluid;
wherein at least one image of said first images and at least one image of said second images being generated in a time no greater than approximately the time between two first images; andiii. a CPU to process said images comprising a computer readable medium containing instructions for generating at least one third image superimposing at least one image of said first images with at least one image of said second images, whereby a high-contrast, high-resolution real-time continuous image of said fluid is obtained b. a fluid inlet in physical connection with said envelope; c. a fluid streamer for streaming a fluid over an individual passing through said fluid stream; d. a separator for separating out particles carried downstream by said fluid stream; and e. a particle collector for collecting said particles to provide a continuous fluid facilitated flow within said inlet to said envelope whereby a high-contrast, high resolution real-time continuous image of said fluid is obtained and the presence of said hazardous biological or chemical agent residues is indicated. - View Dependent Claims (8, 9, 10, 11)
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12. An MRI-based method for screening for the presence of hazardous biological or chemical agent residues carried by an individual, comprising
a. providing an MRI device for providing high contrast high resolution images of a fluid, comprising: -
i. an envelope for least partially confining said fluid; ii. a plurality of magnets located at least partially around said envelope, said assembly comprising; a. a least one first magnet configured to provide a high magnetic field for generating multiple time-resolved one or more first images at high resolution of at least a portion of said fluid; and b. a least one second magnet configured to provide a low magnetic field for generating multiple time-resolved one or more second images at high contrast of at least portion of same said fluid;
wherein at least one image of said first images and at least one image of said second images being generated in a time no greater than approximately the time between two first images; andiii. a CPU to process said images comprising a computer readable medium containing instructions for generating at least one third image superimposing at least one image of said first images with at least one image of said second images, whereby a high-contrast, high-resolution real-time continuous image of said fluid is obtained; a. providing said MRI with a fluid inlet in physical connection with said envelope; b. providing a fluid stream for said individual to pass through; c. streaming fluid over said individual passing through said fluid stream; d. separating out particles carried downstream by said fluid stream; e. collecting said particles by a particle collecting means to provide a continuous fluid facilitated flow within said inlet to said envelope; and f. continuously generating first at least one images, second at least one images and third superimposed at least one images, such that a high-contrast, high resolution real-time continuous image of said fluid is obtained whereby the presence of said hazardous biological or chemical agent residues is indicated. - View Dependent Claims (13, 14, 15, 16)
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17. An MRI-based system for rapidly screening for the presence of hazardous biological or chemical residue in a flowing main fluid, comprising:
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a. an MRI device for providing high contrast high resolution images of a fluid, comprising; i. an envelope for least partially confining said fluid; ii. a plurality of magnets located at least partially around said envelope, said assembly comprising; a. a least one first magnet configured to provide a high magnetic field for generating multiple time-resolved one or more first images at high resolution of at least a portion of said fluid; and b. a least one second magnet configured to provide a low magnetic field for generating multiple time-resolved one or more second images at high contrast of at least portion of same said fluid;
wherein at least one image of said first images and at least one image of said second images being generated in a time no greater than approximately the time between two first images; andiii. a CPU to process said images comprising a computer readable medium containing instructions for generating at least one third image superimposing at least one image of said first images with at least one image of said second images, whereby a high-contrast, high-resolution real-time continuous image of said fluid is obtained; a. a main fluid; b. a purging device to separate an analyzable-size sample of fluid from said main fluid, said separator fluidly connected to said envelope; c. Functionalized Paramagnetic Particles (FPP) with a paramagnetic core and a moiety configured to interact with said biological or chemical agent residues; d. means for mixing said FPP with said analyzable-size sample of fluid; and e. a facilitator to facilitate flow of said fluid mixed with said FPP through said MRI device; whereby a high-contrast, high-resolution real-time continuous image of said at least one analyzable-size sample of said fluid is obtained, and further whereby the presence of said hazardous biological or chemical agent residues in said main fluid is indicated. - View Dependent Claims (18, 19, 20, 21)
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22. An MRI-based method for rapidly screening for the presence of hazardous biological or chemical residue in a flowing main fluid, comprising
a. providing an MRI device for providing high contrast high resolution images of a fluid, comprising: -
i. an envelope for least partially confining said fluid; ii. a plurality of magnets located at least partially around said envelope, said assembly comprising; a. a least one first magnet configured to provide a high magnetic field for generating multiple time-resolved one or more first images at high resolution of at least a portion of said fluid; and b. a least one second magnet configured to provide a low magnetic field for generating multiple time-resolved one or more second images at high contrast of at least portion of same said fluid;
wherein at least one image of said first images and at least one image of said second images being generated in a time no greater than approximately the time between two first images; andiii. a CPU to process said images comprising a computer readable medium containing instructions for generating at least one third image superimposing at least one image of said first images with at least one image of said second images, whereby a high-contrast, high-resolution real-time continuous image of said fluid is obtained; b. purging said main fluid to an analyzable-size sample; c. facilitatedly flowing said purged fluid through said MRI; d. providing Functionalized Paramagnetic Particles (FPP) with a paramagnetic core and a moiety configured to interact with said biological or chemical agent residues; e. introducing said FPP with said purged fluid, f. if said hazardous biological or chemical residue is present in said purged fluid, then interacting said FPP with said biological or chemical agent residues; g. generating multiple time resolved one or more first images at high resolution of at least a portion of said purged fluid; h. generating multiple time resolved one or more second images at high contrast of at least portion of same said purged fluid; i. superimposing at least one image of said first images with at least one image of said second images whereby a high-contrast, high resolution real-time continuous image of said purged fluid is obtained; and j. measuring a change in a nuclear relaxation property of said purged fluid caused by said interaction between said FPP and said biological or chemical agent residues in the applied magnetic field, as indicated by said high-contrast, high resolution real-time continuous image of said purged fluid; and k. correlating said change to the presence of said biological or chemical agent residues in said purged fluid, whereby the presence of said hazardous biological or chemical agent residues in said main fluid is indicated. - View Dependent Claims (23, 24, 25, 26)
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Specification