POLYMER MICROFILTRATION DEVICES, METHODS OF MANUFACTURING THE SAME AND THE USES OF THE MICROFILTRATION DEVICES
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Accused Products
Abstract
A microfilter comprising a polymer layer formed from photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A microfilter comprising two or more polymer layers formed from photo-definable dry film, and a plurality of apertures or open areas each extending through the polymer layer. Methods of forming apertures in one or more layers of photo-definable dry film are also disclosed. Filter holder designs and methods appropriate to hold microfilters to collect the rare cells and to perform of assays in the filter holder are provided. Microfiltration chip designs and methods appropriate to collect the rare cells and to perform assays in the microfluidic chips are provided. The invention also describes the use of the microfilter, filter holder and microfilter chips to collect rare cells from body fluids and perform assays, and these rare cells can be used for medical and biological research applications.
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Citations
51 Claims
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1-26. -26. (canceled)
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27. A filtration device comprising:
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an inlet layer including a first volume and a first inlet layer opening to said first volume; a filter structure including a polymer filter layer having a first filter surface and a second filter surface diametrically opposite to said first filter surface; and an outlet layer including a second volume and a first outlet layer opening to said second volume, wherein said first filter surface is exposed to said first volume, said second filter surface is exposed to said second filter volume, and at least a filtered portion of a sample entering said first inlet layer opening, passes from said first volume to said second volume via said filter layer and exits said second volume via said first outlet layer opening. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35)
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36. A filtration method comprising:
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configuring a filtration device comprising; an inlet layer including a first volume and a first inlet layer opening to said first volume; a filter structure including a polymer filter layer having a first filter surface and a second filter surface diametrically opposite to said first filter surface; and an outlet layer including a second volume and a first outlet layer opening to said second volume, wherein said first filter surface is exposed to said first volume, said second filter surface is exposed to said second filter volume; and passing a liquid sample into said first inlet layer opening whereby at least a filtered portion of a sample entering said first inlet layer opening passes through apertures in the filter from said first volume to said second volume via said filter layer and exits said second volume via said first outlet layer opening, and wherein the apertures are sized to essentially allow passage of a first type of component in the fluid and to substantially prevent passage of a second type of component in the fluid. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44, 47, 48, 49, 50, 51)
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45. A method of configuring a filtration device comprising:
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providing an inlet layer including a first volume and a first inlet layer opening to said first volume; providing a filter structure including a polymer filter layer having a first filter surface and a second filter surface diametrically opposite to said first filter surface; and providing an outlet layer including a second volume and a first outlet layer opening to said second volume, wherein said first filter surface is exposed to said first volume, said second filter surface is exposed to said second filter volume, and at least a filtered portion of a sample entering said first inlet layer opening, passes from said first volume to said second volume via said filter layer and exits said second volume via said first outlet layer opening. - View Dependent Claims (46)
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Specification