Devices and Methods for Separating Magnetically Labeled Moieties in a Sample
First Claim
1. A device for separating magnetically labeled moieties in a sample, the device comprising:
- a magnetic field source;
a first magnetic field guide having a wedge-shaped portion with an apex edge; and
a second magnetic field guide having a wedge-shaped portion with an apex edge,wherein one or more of the first and second magnetic field guides is configured to increase a magnetic flux from the magnetic field source, the apex edges of the first and second magnetic field guides are aligned substantially across from and parallel to each other, and the device is configured to separate magnetically labeled moieties from non-magnetically labeled moieties in the sample.
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Accused Products
Abstract
Devices for separating magnetically labeled moieties in a sample are provided. Aspects of the devices include a magnetic field source, a first magnetic field guide having a wedge-shaped portion with an apex edge, and a second magnetic field guide having a wedge-shaped portion with an apex edge. The apex edge of the first magnetic field guide is aligned substantially across from and parallel to the apex edge of the second magnetic field guide, and the device is configured to separate magnetically labeled moieties from non-magnetically labeled moieties in the sample. Also provided are methods of using the devices, as well as systems and kits configured for use with the devices and methods.
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Citations
15 Claims
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1. A device for separating magnetically labeled moieties in a sample, the device comprising:
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a magnetic field source; a first magnetic field guide having a wedge-shaped portion with an apex edge; and a second magnetic field guide having a wedge-shaped portion with an apex edge, wherein one or more of the first and second magnetic field guides is configured to increase a magnetic flux from the magnetic field source, the apex edges of the first and second magnetic field guides are aligned substantially across from and parallel to each other, and the device is configured to separate magnetically labeled moieties from non-magnetically labeled moieties in the sample. - View Dependent Claims (2, 3, 4, 5)
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6. A method of separating magnetically labeled moieties in a sample, the method comprising:
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(a) positioning in a magnetic separation device a conduit configured to direct a flow of a sample through the magnetic separation device, the magnetic separation device comprising; (i) a magnetic field source; (ii) a first magnetic field guide having a wedge-shaped portion with an apex edge; and (iii) a second magnetic field guide having a wedge-shaped portion with an apex edge, wherein one or more of the first and second magnetic field guides is configured to increase a magnetic flux from the magnetic field source, and the apex edge of the first magnetic field guide is proximal to and substantially parallel to the apex edge of the second magnetic field guide; and (b) applying a magnetic field to separate magnetically labeled moieties from non-magnetically labeled moieties in the sample. - View Dependent Claims (7, 8, 9, 10)
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11. A system for separating magnetically labeled moieties in a sample, the system comprising:
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(a) one or more magnetic separation devices for separating magnetically labeled moieties in the sample, wherein each of the one or more magnetic separation devices comprises; (i) a magnetic field source; (ii) a first magnetic field guide having a wedge-shaped portion with an apex edge; and (iii) a second magnetic field guide having a wedge-shaped portion with an apex edge, wherein one or more of the first and second magnetic field guides is configured to increase a magnetic flux from the magnetic field source, the apex edge of the first magnetic field guide is proximal to and substantially parallel to the apex edge of the second magnetic field guide, and the device is configured to separate magnetically labeled moieties from non-magnetically labeled moieties in the sample; and (b) a conduit positioned in the magnetic separation device and configured to direct a flow of the sample through the magnetic separation device. - View Dependent Claims (12, 13, 14, 15)
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Specification