LIGHT ADDRESSING BIOSENSOR CHIP AND METHOD OF DRIVING THE SAME

• US 20130331295A1
• Filed: 08/14/2013
• Published: 12/12/2013
• Est. Priority Date: 08/28/2009
• Status: Abandoned Application

• Current Assignee: Electronics and Telecommunications Research Institute
• Original Assignee: Electronics and Telecommunications Research Institute
• Inventors: AHN, Chang Geun, PARK, Chan Woo, YANG, Jong Heon, KIM, Tae Youb, AH, Chil Seong, KIM, An Soon, KIM, Bong Kyu, SUNG, Gun Yong, PARK, Seon Hee
• Application Number:
  US13/966,543
• Publication Number:
  US 20130331295A1
• Time in Patent Office: Days
• US Class Current: 506/12
• CPC Class Codes: B01L 2200/0668 Trapping microscopic beads
• CPC Class Codes: B01L 2300/0645 Electrodes
• CPC Class Codes: B01L 2400/043 magnetic forces
• CPC Class Codes: B01L 3/502761 specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules investigating characteristics of particles G01N15/00
• CPC Class Codes: G01N 2035/00158 Elements containing microarrays, i.e. "biochip"
• CPC Class Codes: G01N 2035/00237 Handling microquantities of analyte, e.g. microvalves, capillary networks
• CPC Class Codes: G01N 21/253 for batch operation, i.e. multisample apparatus analytical automats G01N35/00
• CPC Class Codes: G01N 21/75 Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated systems in which material is burnt in a flame or plasma G01N21/72, G01N21/73
• CPC Class Codes: G01N 35/0098 involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation magnetic particles used in immunoassays G01N33/54326; magnetic separation in general B03C
• CPC Class Codes: H01L 27/14601 Structural or functional details thereof

Abstract

Provided is a biosensor chip. The biosensor chip includes a plurality of biosensor cells that are arranged in a matrix and selectively generate and output a sensed signal by addressing of external light, at least one sensing line that is simultaneously connected with the plurality of biosensor cells and transmits the sensed signal from one selected from the biosensor cells, and an output terminal that receives the sensed signal from the sensing line and outputs the sensed signal to an external reader. Thus, the biosensor cells are set in array in the biosensor chip without a separate driving unit, so that a process of manufacturing the biosensor chip is simplified. The biosensor cell to be sensed is selectively addressed through the external light, so that it is possible to reduce a price of the biosensor chip used as a disposable chip.

Claims

1. A biosensor chip comprising:

a plurality of biosensor cells having;

photoelectric elements arranged in a matrix, and selectively turned on to generate a reference electric signal by addressing of external light; and

biosensors receiving the reference electric signal, and generating and outputting a sensed signal caused by a reaction between probe molecules and target molecules on a basis of the reference electric signal;

at least one sensing line simultaneously connected with the plurality of biosensor cells, and transmitting the sensed signal from one selected from the biosensor cells; and

output terminal receiving the sensed signal from the sensing line, and outputting the sensed signal to an external reader.

2. The biosensor chip according to claim 1, wherein the biosensor has resistance changed by the reaction between the probe molecules and the target molecules.

3. The biosensor chip according to claim 1, wherein the photoelectric element includes:

a solar cell generating a turn-on voltage by the addressing of the external light; and

a transistor turned on by the turn-on voltage of the solar cell and transmitting the reference electric signal to the biosensor.

4. The biosensor chip according to claim 3, wherein the transistor includes:

a gate electrode connected with the solar cell and receiving the turn-on voltage;

a source electrode connected with a reference voltage; and

a drain electrode connected with the biosensor and transmitting the reference electric signal based on the reference voltage.

5. The biosensor chip according to claim 1, wherein the photoelectric element includes a phototransistor, which is turned on by the addressing of the external light and transmits the reference electric signal to the biosensor.

6. The biosensor chip according to claim 5, wherein the phototransistor includes a semiconductor layer, from which electron-hole pairs are generated to reduce resistance by the addressing of the external light.

7. The biosensor chip according to claim 5, wherein the phototransistor includes:

a gate electrode connected with a first reference voltage

a source electrode connected with a second reference voltage; and

a drain electrode connected with the biosensor and transmitting the reference electric signal based on the first and second reference voltages.

8. The biosensor chip according to claim 1, wherein:

the plurality of biosensor cells are grouped into a plurality of biosensor cell groups; and

one of the sensing lines is simultaneously connected with the plurality of biosensor cells belonging to one of the biosensor cell groups.

9. The biosensor chip according to claim 1, wherein the output terminals are equal in number to the sensing lines.

10. The biosensor chip according to claim 1, further comprising a power supply terminal, which receives an external supply voltage to apply to the plurality of biosensor cells.

11. The biosensor chip according to claim 2, wherein the probe molecules of each biosensor cell are different from each other.

12-16. -16. (canceled)

17. A method of driving a biosensor chip comprising:

exposing a plurality of biosensor cells arranged in a matrix to a detection sample having target molecules;

selecting at least one of the biosensor cells which is intended to generate and output a sensed signal, and addressing external light to the selected biosensor cell;

turning on a transistor of the selected biosensor cell with the light, and outputting a reference electric signal to a biosensor of the selected biosensor cell; and

generating the sensed signal from the biosensor based on the reference electric signal, and outputting the sensed signal to an output terminal.

18. The method according to claim 17, wherein the sensed signal of the biosensor cell is transmitted to the output terminal through a sensing line connected with the plurality of biosensor cells at the same time.

19. The method according to claim 18, wherein each biosensor cell includes:

a solar cell generating a turn-on voltage with the external light;

a transistor turned on by the turn-on voltage of the solar cell and transmitting the reference electric signal; and

the biosensor receiving the reference electric signal of the transistor to generate the sensed signal changed by a reaction between probe molecules and target molecules.

20. The method according to claim 18, wherein each biosensor cell includes:

a phototransistor having a semiconductor layer from which electron-hole pairs are generated by the external light to reduce resistance, turned on by the external light, and transmitting the reference electric signal; and

the biosensor receiving the reference electric signal of the phototransistor to generate the sensed signal changed by a reaction between probe molecules and target molecules.