GLP-1 POTENTIATORS FROM HEDYCHIUM CORONARIUM AND THEIR APPLICATIONS

• US 20130331323A1
• Filed: 06/06/2013
• Published: 12/12/2013
• Est. Priority Date: 06/06/2012
• Status: Active Grant

• Current Assignee: Development Center for Biotechnology
• Original Assignee: Development Center for Biotechnology
• Inventors: Chen, Hui-Ling, Wu, Yu-Yuan, Huang, Jiann-Jyh, Lee, Shoei-Sheng, Wu, Rey-Yuh, King, K-Lim
• Granted Patent: US 9,150,482 B2
• Time in Patent Office: Days
• US Class Current: 514/7.2
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/11 Aldehydes
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/351 not condensed with another ring
• CPC Class Codes: A61K 31/357 having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
• CPC Class Codes: A61K 31/365 Lactones
• CPC Class Codes: A61K 31/397 having four-membered rings, e.g. azetidine
• CPC Class Codes: A61K 36/9068 Zingiber, e.g. garden ginger
• CPC Class Codes: A61K 38/26 Glucagons
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: C07C 2602/26 the ring system containing ten carbon atoms
• CPC Class Codes: C07C 2603/30 containing seven-membered rings
• CPC Class Codes: C07C 47/225 containing rings other than six-membered aromatic rings
• CPC Class Codes: C07C 47/267 containing rings other than six-membered aromatic rings
• CPC Class Codes: C07C 47/277 containing ether groups, groups, groups, or groups
• CPC Class Codes: C07C 47/46 containing hydroxy groups
• CPC Class Codes: C07D 205/12 condensed with carbocyclic rings or ring systems
• CPC Class Codes: C07D 305/14 condensed with carbocyclic rings or ring systems
• CPC Class Codes: C07D 309/30 Oxygen atoms, e.g. delta-lactones
• CPC Class Codes: C07D 321/04 not condensed with other rings

Abstract

A compound for controlling blood glucose level has a structure shown in Formula I:

wherein R5-R8 are as defined herein. A method for controlling blood glucose level includes administering to a subject in need thereof a compound of Formula I. The method further includes administering to the subject a GLP-1 receptor ligand. The compound and the GLP-1 receptor ligand may be administered together. The compound may be Galanal A or Galanal B. The GLP-1 receptor ligand may be GLP-1 or exendin-4.

Claims

1. A compound for controlling blood glucose level, wherein the compound has a structure shown in Formula I:

2. The compound of claim 1, wherein R₆ and R₇ jointly form ═

CH₂ and the compound has a structure shown in Formula II;

3. The compound of claim 1, wherein the compound has a structure shown in Formula (A) or (B):

4. The compound of claim 1, wherein the compound is selected from compound 1A, 1B, 2, 3, 4, 5, or 6:

5. A method for controlling blood glucose level, comprising administering to a subject in need thereof the compound of claim 1.

6. The method of claim 5, further comprising administering to the subject a glucagon-like peptide-1 (GLP-1) receptor ligand to the subject.

7. The method of claim 6, wherein the GLP-1 receptor ligand is GLP-1 or exendin-4.

8. The method of claim 6, wherein the compound and the GLP-1 receptor ligand are administered together.

9. The method of claim 5, wherein the compound is one selected from compounds having structures shown as compound 1A, 1B, 2, 3, 4, 5, or 6:

10. The method of claim 9, wherein the compound has a structure of 1A.

11. The method of claim 9, wherein the compound has a structure of 1B.