POLYETHER URETHANE AND POLYETHER UREA BASED COPOLYMERS AND METHODS RELATED THERETO

• US 20130331537A1
• Filed: 06/07/2013
• Published: 12/12/2013
• Est. Priority Date: 06/08/2012
• Status: Abandoned Application

• Current Assignee: Poly-Med, Inc.
• Original Assignee: Poly-Med, Inc.
• Inventors: Gray, Kenneth David Jr., Corbett, Joel Thomas, Hilas, Georgios Theofanis
• Application Number:
  US13/913,217
• Publication Number:
  US 20130331537A1
• Time in Patent Office: Days
• US Class Current: 528/61
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: C08G 18/12 using two or more compounds having active hydrogen in the first polymerisation step
• CPC Class Codes: C08G 18/3228 acyclic
• CPC Class Codes: C08G 18/4018 Mixtures of compounds of group C08G18/42 with compounds of group C08G18/48
• CPC Class Codes: C08G 18/44 Polycarbonates
• CPC Class Codes: C08G 18/4808 Mixtures of two or more polyetherdiols
• CPC Class Codes: C08G 18/4841 containing oxyethylene end groups
• CPC Class Codes: C08G 18/485 containing mixed oxyethylene-oxypropylene or oxyethylene-higher oxyalkylene end groups
• CPC Class Codes: C08G 18/4854 Polyethers containing oxyalkylene groups having four carbon atoms in the alkylene group
• CPC Class Codes: C08G 18/5024 containing primary and/or secondary amino groups
• CPC Class Codes: C08G 18/724 Combination of aromatic polyisocyanates with (cyclo)aliphatic polyisocyanates
• CPC Class Codes: C08G 18/73 acyclic
• CPC Class Codes: C08G 18/7671 containing only one alkylene bisphenyl group
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

Polymeric materials referred to herein as PEU include a plurality of linking groups selected from urea and urethane groups, and a plurality of segments located between adjacent linking groups, where at least some of the segments of the PEU are polyoxyalkylene, but other exemplary segments include hydrocarbons, polyesters, polycarbonates and polysiloxanes. The polymeric materials are biocompatible and may be used, for example, to replace or supplement cartilage in an articulated joint.

Claims

1. A polymer composition which is the reaction product of a pre-polymer and a diamine, where the pre-polymer is the reaction product of a diisocyanate and a polyetherdiol.

2. The polymer of claim 1 wherein the polyetherdiol comprises at least one type of oxyalkylene sequence selected from the group consisting of oxyethylene, oxypropylene, oxytrimethylene and oxytetramethylene sequences.

3. The polymer of claim 1 wherein the polyetherdiol is a blend of polyetherdiols.

4. The polymer of claim 1 wherein the polyetherdiol comprises a block copolymer of two or more oxyalkylene sequences.

5. The polymer of claim 1 wherein the diamine is an aliphatic diamine.

6. The polymer of claim 1 wherein the diisocyanate is an aliphatic diisocyanate.

7. The polymer claim 1 which is bio-stable.

8. The polymer of claim 1 which absorbs at least 50% of its weight in water when immersed in 1% aqueous methyl cellulose at 37°

C. for 16 hours.

9. The polymer of claim 1 which has a COF of 0.001 to 0.15.

10. The polymer of claim 1 which has an intrinsic viscosity of 3-8 dl/g.

11. A polymer composition which is the reaction product of a pre-polymer and a polyetherdiol, where the pre-polymer is the reaction product of a diisocyanate and a diamine.

12. The polymer of claim 11 wherein the polyetherdiol comprises at least one type of oxyalkylene sequence selected from the group consisting of oxyethylene, oxypropylene, oxytrimethylene and oxytetramethylene sequences.

13. The polymer of claim 11 wherein the polyetherdiol is a blend of polyetherdiols.

14. The polymer of claim 11 wherein the polyetherdiol comprises a block copolymer of two or more oxyalkylene sequences.

15. The polymer of claim 11 wherein the diamine is an aliphatic diamine.

16. The polymer of claim 11 wherein the diisocyanate is an aliphatic diisocyanate.

17. The polymer claim 11 which is bio-stable.

18. The polymer of claim 11 which absorbs at least 50% of its weight in water when immersed in 1% aqueous methyl cellulose at 37°

C. for 16 hours.

19. The polymer of claim 11 which has a COF of 0.001 to 0.15.

20. The polymer of claim 11 which has an intrinsic viscosity of 3-8 dl/g.