APPLICATION OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY IN SENSOR SYSTEMS, DEVICES, AND RELATED METHODS
First Claim
1. A sensor system, comprising:
- a subcutaneous or implanted sensor, said sensor having a plurality of independent working electrodes, a counter electrode, and a reference electrode; and
sensor electronics operably coupled to said sensor and including;
electronic circuitry configured to selectively perform an electrochemical impedance spectroscopy (EIS) procedure for one or more of said plurality of independent working electrodes to generate impedance-related data for said one or more working electrodes;
a programmable sequencer configured to provide a start stimulus and a stop stimulus for performing said EIS procedure; and
a microcontroller interface configured to operably couple the sensor electronics to a microcontroller.
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Abstract
A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.
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Citations
16 Claims
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1. A sensor system, comprising:
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a subcutaneous or implanted sensor, said sensor having a plurality of independent working electrodes, a counter electrode, and a reference electrode; and sensor electronics operably coupled to said sensor and including; electronic circuitry configured to selectively perform an electrochemical impedance spectroscopy (EIS) procedure for one or more of said plurality of independent working electrodes to generate impedance-related data for said one or more working electrodes; a programmable sequencer configured to provide a start stimulus and a stop stimulus for performing said EIS procedure; and a microcontroller interface configured to operably couple the sensor electronics to a microcontroller. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification