SYSTEMS AND METHODS FOR RUN-TIME SEQUENCING RUN QUALITY MONITORING
First Claim
1. A system for sequencing nucleic acid samples, the system comprising:
- a sequencing instrument for interrogating a control set and a nucleic acid sample for producing control data for the control set and sample data for the nucleic acid sample; and
a processor in communication with the sequencing instrument configured to;
receive the control data and the sample data from the sequencing instrument;
compare the control data to the sample data; and
perform an event handling routine based on the comparison of the control data to the sample data.
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Accused Products
Abstract
Systems and methods of providing run-time quality control and monitoring of a single or multiple sequencing runs are provided herein. In some embodiments, the run-time system includes or is in communication with a processor capable of determining various types of run-time information relating to the quality, progress, etc. of various sequencing runs. In some embodiments, the system can also be in communication with a user interface, for example, a GUI, capable of representing and communicating various types of information to a user regarding the quality of the individual or multiple runs, the functioning of the instrument, an error event, etc. Additionally, the system can capable of receiving actionable information from a user via the GUI thereby allowing the user to terminate or repeat various sequencing steps in a particular run, terminate a entire run, terminate all runs, allow a run to proceed, etc.
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Citations
20 Claims
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1. A system for sequencing nucleic acid samples, the system comprising:
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a sequencing instrument for interrogating a control set and a nucleic acid sample for producing control data for the control set and sample data for the nucleic acid sample; and a processor in communication with the sequencing instrument configured to; receive the control data and the sample data from the sequencing instrument; compare the control data to the sample data; and perform an event handling routine based on the comparison of the control data to the sample data. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A computer-implemented method comprising:
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receiving control data and sample data from a sequencing instrument, determining a control quality value for the control data and a sample quality value for the sample data; comparing the control quality value for the control data to an expected control quality value; and
the sample quality value for the sample data to an expected sample quality value;determining an event condition based on the comparison. - View Dependent Claims (9, 10, 11, 12, 13)
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14. A computer program product, comprising a non-transitory computer-readable storage medium whose contents include a program with instructions being executed on a processor, the instructions comprising:
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instructions to obtain control data and sample data from a sequencing instrument, instructions to determine a control quality value for the control data and a sample quality value for the sample data; instructions to compare the control quality value and the sample quality value; instructions to perform an event handling routine when the control quality value or the sample quality value is below a threshold. - View Dependent Claims (15, 16, 17, 18, 19)
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20-32. -32. (canceled)
Specification