Process for Predicting Hematocrit of Whole Blood Using IR Light
First Claim
1. In a blood processing procedure in which blood is processed into one or more blood components with a single-use processing kit, the processing kit including tubing through which the blood is flowed, and a reusable hardware module onto which the processing kit is mounted, the reusable hardware module including a sensing field defined by an infrared light source and an infrared reflectance sensor that receives a segment of the tubing, a method for predicting the hematocrit of the blood comprising:
- loading the processing kit onto the hardware module with a segment of the tubing positioned in the sensing field defined by the infrared light source and the infrared reflectance sensor;
obtaining an infrared reflectance measurement of the segment of the tubing with either no fluid or a non-reflecting fluid within said segment;
flowing blood through the segment of the tubing;
obtaining an infrared reflectance measurement of the segment of the tubing with said blood;
deriving the natural log of the infrared reflectance measurement attributable to the presence of blood in the segment of the tubing;
inputting the natural log of the infrared reflectance attributable to the blood in the segment of the tubing into a correlation equation to arrive at the hematocrit of the blood;
outputting the predicted hematocrit of the blood.
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Abstract
A separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided. Automated systems and methods are disclosed for separating a unit of previously-collected whole blood into selected blood components, such as concentrated red cells and plasma, including prediction of the hematocrit of the whole blood using a light source and an optical sensor.
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Citations
17 Claims
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1. In a blood processing procedure in which blood is processed into one or more blood components with a single-use processing kit, the processing kit including tubing through which the blood is flowed, and a reusable hardware module onto which the processing kit is mounted, the reusable hardware module including a sensing field defined by an infrared light source and an infrared reflectance sensor that receives a segment of the tubing, a method for predicting the hematocrit of the blood comprising:
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loading the processing kit onto the hardware module with a segment of the tubing positioned in the sensing field defined by the infrared light source and the infrared reflectance sensor; obtaining an infrared reflectance measurement of the segment of the tubing with either no fluid or a non-reflecting fluid within said segment; flowing blood through the segment of the tubing; obtaining an infrared reflectance measurement of the segment of the tubing with said blood; deriving the natural log of the infrared reflectance measurement attributable to the presence of blood in the segment of the tubing; inputting the natural log of the infrared reflectance attributable to the blood in the segment of the tubing into a correlation equation to arrive at the hematocrit of the blood; outputting the predicted hematocrit of the blood. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A reusable hardware module for use with a single-use processing kit for processing blood, the reusable module comprising:
a programmable controller with an input for receipt of a first signal corresponding to an infrared reflectance measurement obtained from the processing kit and an output for transmitting a second signal corresponding to a predicted hematocrit for the blood being processed, the programmable controller being configured to derive the natural log of the infrared reflectance measurement, inputting the natural log of the infrared reflectance measurement into a pre-determined correlation equation, generating the second signal corresponding to the predicted hematocrit, and transmitting the second signal to an interface.
Specification