PULSATILE RELEASE OF MEDICAMENTS FROM A PUNCTAL PLUG
First Claim
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1. A punctal plug for delivering an active agent, the punctal plug comprising:
- a body comprising a first end, and a second end, wherein the first end is capable of being inserted in a human punctum;
a tube inserted into a cavity in the punctual plug body;
an area comprising the second end of the punctal plug which is more conductive to elution of the active agent than the body of the punctal plug; and
two or more pulsatile delivery units arranged in a generally linear fashion within the tube, each unit comprising an active agent bead encapsulated by a water soluble layer, wherein each active agent bead comprises generally equal volumes and concentrations of an active agent, and wherein the arrangement of the pulsatile delivery units allow for a release of the active agent from the tube in multiple pulses of the active agent when the plug is exposed to tear fluid.
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Abstract
This invention discloses methods and apparatus for providing pulsatile release of active agents via a punctal plug inserted into a punctum. A tube is provided which may be inserted into a cavity of a punctal plug. One or more pulsatile delivery units are arranged in a generally linear fashion within the tube. The pulsatile delivery units include a core comprising the active agent and an encapsulation layer around the core.
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Citations
15 Claims
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1. A punctal plug for delivering an active agent, the punctal plug comprising:
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a body comprising a first end, and a second end, wherein the first end is capable of being inserted in a human punctum; a tube inserted into a cavity in the punctual plug body; an area comprising the second end of the punctal plug which is more conductive to elution of the active agent than the body of the punctal plug; and two or more pulsatile delivery units arranged in a generally linear fashion within the tube, each unit comprising an active agent bead encapsulated by a water soluble layer, wherein each active agent bead comprises generally equal volumes and concentrations of an active agent, and wherein the arrangement of the pulsatile delivery units allow for a release of the active agent from the tube in multiple pulses of the active agent when the plug is exposed to tear fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification