USE OF MICROFLUIDIC SYSTEMS IN THE DETECTION OF TARGET ANALYTES USING MICROSPHERE ARRAYS
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Abstract
The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes.
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Citations
33 Claims
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1-18. -18. (canceled)
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19. A method of sequencing a nucleic acid comprising:
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providing a fluidics device comprising; a first channel in fluid communication with an inlet, a detection module in fluid communication with said first channel, said detection module comprising an array of wells in communication with a tantalum-containing substrate, a population of microspheres comprising at least a first and a second subpopulation, wherein each subpopulation comprises a bioactive agent and wherein said microspheres are distributed in said wells such that not more than one microsphere is present in each of the wells, and a second channel in fluid communication with said detection module and an outlet; providing a fluid comprising a target nucleic acid to the inlet; and sequencing the target nucleic acid. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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Specification