Automated Prevention and Control of Epileptic Seizures Using Biochemical And/or Electrical Signal Markers
First Claim
Patent Images
1. A non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform a method, comprising:
- determining at least one of (i) a concentration of at least one polyamine selected from putrescine, spermidine, spermine, or γ
-aminobutyric acid (GABA) in a brain of a patient, (ii) a concentration of a substrate for synthesis of putrescine, spermidine, spermine, or GABA in said brain of said patient, (iii) a concentration or an activity level of an enzyme for synthesis of putrescine, spermidine, spermine, or GABA in said brain of said patient, or (iv) a concentration of a metabolite of one of putrescine, spermidine, spermine, or GABA in said brain of said patient; and
taking a further action selected from;
issuing a warning if said concentration or activity level is below a first reference value;
indicating a lower probability or likelihood of an epileptic event if said concentration or activity level is above a second reference value;
increasing said concentration if said concentration or activity level is below a third reference value;
ormaintaining said concentration or activity level above a fourth reference value.
1 Assignment
0 Petitions
Accused Products
Abstract
Methods and medical device systems for preventing or abating seizures, making use of an association between the probability or likelihood of seizure occurrence and the concentrations or activity levels of one or more of putrescine, spermidine, spermine, or γγ-aminobutyric acid (GABA). The concentration or activity level of putrescine, spermidine, spermine, or GABA, or a substrate or enzyme for synthesis thereof, may be determined, and at least one further action may be performed.
-
Citations
12 Claims
-
1. A non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform a method, comprising:
-
determining at least one of (i) a concentration of at least one polyamine selected from putrescine, spermidine, spermine, or γ
-aminobutyric acid (GABA) in a brain of a patient, (ii) a concentration of a substrate for synthesis of putrescine, spermidine, spermine, or GABA in said brain of said patient, (iii) a concentration or an activity level of an enzyme for synthesis of putrescine, spermidine, spermine, or GABA in said brain of said patient, or (iv) a concentration of a metabolite of one of putrescine, spermidine, spermine, or GABA in said brain of said patient; andtaking a further action selected from; issuing a warning if said concentration or activity level is below a first reference value; indicating a lower probability or likelihood of an epileptic event if said concentration or activity level is above a second reference value; increasing said concentration if said concentration or activity level is below a third reference value;
ormaintaining said concentration or activity level above a fourth reference value. - View Dependent Claims (2, 3, 4, 8, 9)
-
-
5. A non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform a method, comprising:
-
determining an occurrence of a seizure in a patient; increasing a concentration of at least one polyamine selected from putrescine, spermidine, spermine, or γ
-aminobutyric acid (GABA) in a brain of said patient, a concentration of a substrate for synthesis of putrescine, spermidine, spermine, or GABA in said brain, or a concentration or an activity level of an enzyme for synthesis of putrescine, spermidine, spermine, or GABA in said brain in response to said determining, within a predetermined time period after the occurrence of said seizure. - View Dependent Claims (6, 7)
-
-
10. A medical device system, comprising:
-
(i) at least one sensor configured to collect data relating to at least one of;
a concentration of a polyamine selected from putrescine, spermidine, spermine, or γ
-aminobutyric acid (GABA);
a concentration of a substrate for synthesis of putrescine, spermidine, spermine, or GABA;
a concentration of a metabolite of putrescine, spermidine, spermine, or GABA;
or a concentration or an activity level of an enzyme for synthesis of putrescine, spermidine, spermine, or GABA;
in a brain of a patient;(ii) at least one processor configured to; (ii-a) determine said concentration or said activity level of said polyamine, said substrate, said metabolite, or said enzyme from said collected data; (ii-b) perform one or more of; (ii-b-1) estimate a future concentration or activity level of at least one polyamine, said substrate, said metabolite, or said enzyme; (ii-b-2) compare said concentration or activity level to a reference value;
or(ii-b-3) determine, as function of said concentration or activity level, a probability or likelihood of an occurrence of at least one seizure during a first time window; and (ii-c) issue a signal relating to a further action, based on at least one of said estimated future concentration or activity level, said compared concentration or activity level, or said determined probability or likelihood; and at least one of; (iii) a warning unit configured to provide a warning relating to at least one of said estimated future concentration or activity level, said compared concentration or activity level, or said determined probability or likelihood; (iv) a concentration increasing unit configured to increase said concentration or activity level, based on at least one of said estimated future concentration or activity level, said compared concentration or activity level, or said determined probability or likelihood. (v) a probability indication unit configured to indicate a lower probability of an epileptic event, based on at least one of said estimated future concentration or activity level, said compared concentration or activity level, or said determined probability or likelihood;
or(vi) a concentration maintaining unit configured to maintain said concentration or activity level, based on at least one of said estimated future concentration or activity level, said compared concentration or activity level, or said determined probability or likelihood. - View Dependent Claims (11, 12)
-
Specification