METHOD FOR ESTIMATING CENTRAL AORTIC PULSE PRESSURE BY CUFF PRESSURE PULSE WAVE OSCILLATION SIGNALS AND DEVICE THEREOF

• US 20130345576A1
• Filed: 12/13/2012
• Published: 12/26/2013
• Est. Priority Date: 06/20/2012
• Status: Active Grant

• Current Assignee: National Yang-Ming University
• Original Assignee: National Yang-Ming University
• Inventors: CHEN, Chen-Huan, CHENG, Hao-Mim, SUNG, Shih-Hsien
• Granted Patent: US 9,510,760 B2
• Time in Patent Office: Days
• US Class Current: 600/490
• CPC Class Codes: A61B 5/02225 using the oscillometric method

Abstract

The present invention provides a method for estimating central aortic pulse pressure by cuff pressure pulse wave oscillation signals, comprising: (I) providing an equation for estimating central aortic pulse pressure; (II) measuring pressure pulse wave oscillation signals in a cuff, which comprise a brachial systolic blood pressure, a diastolic blood pressure and a waveform of the pressure pulse wave oscillation signals in the cuff; (III) averaging the waveform of the pressure pulse wave oscillation signals and calibrating the averaged waveform by the systolic blood pressure and diastolic blood pressure; (IV) analyzing the calibrated pressure pulse wave oscillation signal waveform to obtain a plurality predicting variables; and (V) obtaining an estimate of central aortic pulse pressure by values of predicting variables in step (IV) and the equation in step (I). The present invention further provides a device for estimating central aortic pulse pressure by the method of the present invention.

Claims

1. A method for estimating central aortic pulse pressure by a pressure pulse wave oscillation signal of a cuff, comprising:

(I) providing an equation for estimating a central aortic pulse pressure;

(II) measuring the pressure pulse wave oscillation signal in the cuff, comprising a brachial systolic blood pressure, a diastolic blood pressure and a waveform of pressure pulse wave oscillation signals in the cuff;

(III) averaging the waveform of the pressure pulse wave oscillation signals and calibrating the averaged waveform by the systolic blood pressure and the diastolic blood pressure;

(IV) analyzing the calibrated waveform of the pressure pulse wave oscillation signals to obtain a plurality of characteristic signal values, in which a characteristic signal serves as a predicting variable, and predicting variables comprising;

(a) end-systolic pressure (ESP), (b) areas under a pressure tracing in systole (As), (c) areas under a pressure tracing in diastole (Ad), (d) diastolic blood pressure (DBP) and (e) heart rate (HR); and

(V) obtaining an estimate of the central aortic pulse pressure by substituting values of the predicting variables of step (IV) into the equation of step (I).

2. The method as claimed in claim 1, wherein the equation for estimating the central aortic pulse pressure obtains a plurality of the predicting variables and predicting coefficients by linear regression analysis.

3. The method as claimed in claim 1, wherein the equation for estimating the central aortic pulse pressure is:

a+b*ESP+c*As +d*Ad+e*DBP+PHR, wherein a, b, c, d, e and f are variable coefficients of the equation for estimating the central aortic pulse pressure.

4. The method as claimed in claim 3, wherein the equation for estimating the central aortic pulse pressure is:

−

88.2+0.79*ESP+1.41*As +0.68*Ad−

1.16*DBP+0.84*HR.

5. The method as claimed in claim 1, wherein the central artery is carotid artery or ascending aorta.

6. The method as claimed in claim 1, wherein the signal of the cuff is a signal from brachial artery.

7. A device for estimating central aortic pulse pressure by a pressure pulse wave oscillation signal of a cuff, comprising:

(a) means for regulating a pressure of the cuff, which is used to control the proceeding of pressurization, maintenance and decompression in a measured location of the cuff;

(b) means for recording and storing the pressure pulse wave oscillation signal of the cuff; and

(c) means for analyzing the central aortic pulse pressure, comprising storing means for storing a equation for estimating the central aortic pulse pressure to calculate in real-time an estimate of the central aortic pulse pressure by a value of a predicting variable,

wherein the equation comprises a plurality of predicting variables and predicting coefficients, and wherein the predicting variables comprise (a) end-systolic pressure (ESP), (b) areas under a pressure tracing in systole (As), (c) areas under a pressure tracing in diastole (Ad), (d) diastolic blood pressure (DBP) and (e) heart rate (HR).

8. The device as claimed in claim 7, wherein the equation for estimating the central aortic pulse pressure obtains the plurality of the predicting variables and predicting coefficients by linear regression analysis.

9. The device as claimed in claim 7, wherein the equation for estimating the central aortic pulse pressure is:

a+b*ESP+c*As +d*Ad+e*DBP+f*HR, wherein a, b, c, d, e and f is variable coefficient of the equation for estimating central aortic pulse pressure, wherein a, b, c, d, e and f are variable coefficients of the equation for estimating central aortic pulse pressure.

10. The device as claimed in claim 9, wherein the equation for estimating central aortic pulse pressure is:

−

88.2+0.79*ESP+1.41*As +0.68*Ad−

1.16*DBP+0.84*HR.

11. The device as claimed in claim 7, wherein the central artery is carotid artery or ascending aorta.

12. The device as claimed in claim 7, wherein the measured location is brachial artery.

13. The device as claimed in claim 7, wherein the storing means is a chip or a memory storage device.