MICRONEEDLE-CONTAINING DRUG DELIVERY DEVICE TO BE ATTACHED TO EXTERIOR WALL OF VASCULAR VESSEL AND METHOD FOR DRUG DELIVERY THEREWITH
First Claim
1. A drug delivery device for attachment to the outer wall of a blood vessel, the blood delivery device comprising:
- a) a body made of a biocompatible material and formed so as to cover the blood vessel;
b) one or more needles made of a biocompatible material, which are connected to the inside of the body and inserted into the tunica media of the blood vessel so as to deliver a drug to vascular smooth muscle cells;
c) one or more drug reservoirs formed in the body; and
d) microchannels formed in the needles and serving to deliver the drug from the drug reservoirs to the tunica media of the blood vessel.
1 Assignment
0 Petitions
Accused Products
Abstract
A drug delivery device, which is to be attached to the exterior wall of a vascular vessel, includes: a) a biocompatible device body for surrounding a vascular vessel; b) one or plurality of biocompatible microneedle, which are connected to the interior of the biocompatible device body and capable of penetrating up to the tunica media so as to deliver drug to the vascular smooth muscle cells. The drug delivery device and method enable spatial and temporal control of the drug ejected onto the blood cells and enable insertions of two or more different drugs at different delivery speeds and durations, thereby significantly improving the treatment success rate.
48 Citations
35 Claims
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1. A drug delivery device for attachment to the outer wall of a blood vessel, the blood delivery device comprising:
- a) a body made of a biocompatible material and formed so as to cover the blood vessel;
b) one or more needles made of a biocompatible material, which are connected to the inside of the body and inserted into the tunica media of the blood vessel so as to deliver a drug to vascular smooth muscle cells;
c) one or more drug reservoirs formed in the body; and
d) microchannels formed in the needles and serving to deliver the drug from the drug reservoirs to the tunica media of the blood vessel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- a) a body made of a biocompatible material and formed so as to cover the blood vessel;
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9. A drug delivery device for attachment to the outer wall of a blood vessel, the blood delivery device comprising:
- a) a body made of a biocompatible material and formed so as to cover the blood vessel;
b) one or more needles made of a biocompatible material, which are connected to the inside of the body and inserted into the tunica media of the blood vessel; and
c) a mixture of a biocompatible material and a drug, which is delivered to vascular smooth muscle cells through the needles. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
- a) a body made of a biocompatible material and formed so as to cover the blood vessel;
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17. A drug delivery device for attachment to the outer wall of a blood vessel, the blood delivery device comprising:
- a) a body made of a biocompatible material and formed so as to cover the blood vessel; and
b) one or more needles made of a biocompatible material, which are connected to the inside of the body and inserted into the tunica media of the blood vessel so as to deliver a drug to vascular smooth muscle cells. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25)
- a) a body made of a biocompatible material and formed so as to cover the blood vessel; and
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26. A method for preparing a drug delivery device for attachment to the outer wall of a blood vessel, the method comprising the steps of:
- a) fabricating a body formed so as to cover a blood vessel; and
b) fabricating one or more needles that are connected to the inside of the body and inserted into the tunica media of the blood vessel so as to deliver a drug to vascular smooth muscle cells. - View Dependent Claims (27, 28, 29, 30, 31)
- a) fabricating a body formed so as to cover a blood vessel; and
- 32. A method for delivering a drug using a body made of a biocompatible material and formed so as to cover a blood vessel, a plurality of needles connected to the body and inserted into the tunica media of the blood vessel, a plurality of drug reservoirs formed in the body, and microchannels formed in the needles and serving to deliver the drug from the drug reservoirs to the tunica media of the blood vessel, wherein the number of the needles, the size of the drug reservoirs or the structure of the microchannels is controlled to control a region into which the drug is administered, the amount of drug administered and the period of administration of the drug.
- 34. A method for delivering a drug using a) a body made of a biocompatible material and formed so as to cover a blood vessel, a plurality of needles connected to the inside of the body and inserted into the tunica media of the blood vessel, and a mixture of a biocompatible material and the drug, which is delivered to vascular smooth muscle cells through the needles, or b) a body made of a biocompatible material and formed so as to cover a blood vessel, and one or more needles connected to the inside of the body and made of a biocompatible material mixed with the drug so as to deliver the drug to vascular smooth muscle cells, wherein the degradation rate of the biocompatible material or the mixing ratio between the biocompatible material and the drug is controlled to control the amount of drug administered and the period of administration of the drug.
Specification