ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS
First Claim
1. An electrochemical sensor for determining a presence or a concentration of an analyte in a fluid, the sensor comprising:
- a membrane system comprising an enzyme, wherein the enzyme reacts with the analyte;
an electroactive surface comprising a working electrode, the working electrode comprising a conductive material and configured to measure a product of the reaction of the enzyme with the analyte; and
an auxiliary electrode comprising a conductive material and configured to modify an electrochemical interferent such that the electrochemical interferent is rendered substantially electrochemically non-reactive at the working electrode.
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Accused Products
Abstract
The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode advantageously improves oxygen availability to the enzyme and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants.
10 Citations
18 Claims
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1. An electrochemical sensor for determining a presence or a concentration of an analyte in a fluid, the sensor comprising:
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a membrane system comprising an enzyme, wherein the enzyme reacts with the analyte; an electroactive surface comprising a working electrode, the working electrode comprising a conductive material and configured to measure a product of the reaction of the enzyme with the analyte; and an auxiliary electrode comprising a conductive material and configured to modify an electrochemical interferent such that the electrochemical interferent is rendered substantially electrochemically non-reactive at the working electrode. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. An electrochemical sensor comprising:
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an electroactive surface configured to measure an analyte; and an auxiliary interferent-modifying electrode configured to modify an electrochemical interferant such that the electrochemical interferent is rendered substantially non-reactive at the electroactive surface. - View Dependent Claims (16, 17, 18)
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Specification