USE OF QUORUM SENSING INHIBITORS AND BIOFILM DISPERSING AGENTS FOR CONTROLLING BIOFILM-ASSOCIATED IMPLANTABLE MEDICAL DEVICE RELATED INFECTIONS

• US 20140005605A1
• Filed: 06/28/2012
• Published: 01/02/2014
• Est. Priority Date: 06/28/2012
• Status: Abandoned Application

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Samade, Richard, Dinesh, Prashant, Nabutovsky, Yelena, Bornzin, Gene A., Poore, John W., Karicherla, Annapurna, Dalal, Nirav
• Application Number:
  US13/536,848
• Publication Number:
  US 20140005605A1
• Time in Patent Office: Days
• US Class Current: 604/131
• CPC Class Codes: A61M 2205/0205 Materials having antiseptic or antimicrobial properties, e.g. silver compounds, rubber with sterilising agent
• CPC Class Codes: A61M 2205/0238 the material being a coating or protective layer
• CPC Class Codes: A61M 5/00 Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests vaccination appliances for veterinary use A61D1/025 ; tube connectors, tube couplings, valves or branch units specially adapted for medical use A61M39/00; containers specially adapted for medical or pharmaceutical purposes A61J1/00; combinations of vial and syringe for mixing or transferring their contents A61J1/20; holders for containers for collecting, storing or administering blood or medical fluids A61J1/16
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: C08K 5/1539 Cyclic anhydrides
• CPC Class Codes: C08K 5/3432 Six-membered rings
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00
• CPC Class Codes: C09D 129/04 Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• CPC Class Codes: C09D 133/066 containing -OH groups
• CPC Class Codes: C09D 133/10 Homopolymers or copolymers of methacrylic acid esters
• CPC Class Codes: C09D 139/06 Homopolymers or copolymers of N-vinyl-pyrrolidones
• CPC Class Codes: C09D 167/00 Coating compositions based on polyesters obtained by reactions forming a carboxylic ester link in the main chain based on polyester-amides C09D177/12; based on polyester-imides C09D179/08; Coating compositions based on derivatives of such polymers
• CPC Class Codes: C09D 167/02 Polyesters derived from dicarboxylic acids and dihydroxy compounds C09D167/06 takes precedence
• CPC Class Codes: C09D 175/04 Polyurethanes

Abstract

A coating on at least a portion of an implantable medical device includes a polymer and an agent that inhibits the formation of biofilms. The agent inhibiting the formation of a biofilm includes a quorum sensing inhibitor (QSI), a biofilm dispersing agent (BDA) or both. The agent may also be delivered via an actuator associated with the implantable medical device.

Claims

1. An implantable medical device comprising a coating on at least a portion of the device, wherein the coating comprises a polymer and an agent that inhibits the formation of biofilms.

2. The implantable medical device of claim 1, wherein the polymer comprises a hydrophilic polymer.

3. The implantable medical device of claim 2, wherein the agent comprises a quorum sensing inhibitor.

4. The implantable medical device of claim 3, wherein the quorum sensing inhibitor is selected from the group consisting of 4-nitropyridine-N-oxide, furanone C-30 and RNA III inhibiting peptide.

5. The implantable medical device of claim 3, wherein the quorum sensing inhibitor is covalently bonded to the hydrophilic polymer.

6. The implantable medical device of claim 2, wherein the agent comprises a biofilm dispersal agent.

7. The implantable medical device of claim 6, wherein the biofilm dispersal agent is selected from the group consisting of cis-2-decanoic acid, alginate lyase and dispersin B polypeptide.

8. The implantable medical device of claim 6, wherein the biofilm dispersal agent is covalently bonded to the hydrophilic polymer.

9. The implantable medical device of claim 1, wherein the polymer comprises a hydrophobic polymer.

10. The implantable medical device of claim 9, wherein the agent comprises a quorum sensing inhibitor.

11. The implantable medical device of claim 10, wherein the quorum sensing inhibitor is selected from the group consisting of 4-nitropyridine-N-oxide, furanone C-30 and RNA Ill inhibiting peptide.

12. The implantable medical device of claim 10, wherein the quorum sensing inhibitor is covalently bonded to the hydrophobic polymer.

13. The implantable medical device of claim 9, wherein the agent comprises a biofilm dispersal agent.

14. The implantable medical device of claim 13, wherein the biofilm dispersal agent is selected from the group consisting of cis-2-decanoic acid, alginate lyase and dispersin B polypeptide.

15. The implantable medical device of claim 13, wherein the biofilm dispersal agent is covalently bonded to the hydrophobic polymer.

16. The implantable medical device of claim 2, wherein the agent is dispersed within the hydrophilic coating.

17. The implantable medical device of claim 9, wherein the agent is dispersed within the hydrophobic coating.

18. A method of controlling the formation of a biofilm on an implantable medical device comprising applying a coating on a portion of said device, wherein the coating is selected from the group consisting of a hydrophilic polymer and a hydrophobic polymer, and wherein the coating further comprises an agent that inhibits the formation of biofilms.

19. The method according to claim 18, wherein the agent is selected from the group consisting of a quorum sensing inhibitor and a biofilm dispersal agent.

20. A method for manufacturing an implantable medical device comprising:

forming a housing for the implantable medical device from a biocompatible material; and

applying to an exterior surface of the housing a coating selected from the group consisting of a hydrophilic polymer and a hydrophobic polymer, wherein the coating further comprises an agent that inhibits the formation of biofilms.

21. The method of claim 20, wherein the agent is selected from the group consisting of a quorum sensing inhibitor and a biofilm dispersal agent.

22. An implantable medical device comprising:

a housing; and

an actuator disposed within the housing, wherein the actuator is configured to deliver to an exterior surface of the housing an agent that inhibits the formation of biofilms, wherein the agent is selected from the group consisting of a quorum sensing inhibitor and a biofilm dispersal agent.

23. The implantable medical device of claim 22, wherein the quorum sensing inhibitor is selected from the group consisting of 4-nitropyridine-N-oxide, furanone C-30 and RNA III inhibiting peptide.

24. The implantable medical device of claim 22, wherein the biofilm dispersal agent is selected from the group consisting of cis-2-decanoic acid, alginate lyase and dispersin B polypeptide.