ASEPTIC CARTRIDGE AND DISPENSER ARRANGEMENT

• US 20140008366A1
• Filed: 01/17/2012
• Published: 01/09/2014
• Est. Priority Date: 01/17/2011
• Status: Active Grant

• Current Assignee: Aktivax, Inc.
• Original Assignee: Aktivpak, Inc.
• Inventors: Genosar, Amir
• Granted Patent: US 11,759,572 B2
• Time in Patent Office: Days
• US Class Current: 220/265
• CPC Class Codes: A61J 1/2024 having peelable seals
• CPC Class Codes: A61J 1/2093 Containers having several compartments for products to be mixed
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: A61M 2005/3104 Caps for syringes without needle
• CPC Class Codes: A61M 2005/3118 via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
• CPC Class Codes: A61M 2005/3121 via the proximal end of a syringe, i.e. syringe end opposite to needle cannula mounting end
• CPC Class Codes: A61M 2205/19 Constructional features of carpules, syringes or blisters
• CPC Class Codes: A61M 5/002 Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics needle protection, e.g. caps, A61M5/3202; for sharps A61B50/3001
• CPC Class Codes: A61M 5/1782 Devices aiding filling of syringes in situ combination of a vial and a syringe for transferring or mixing their contents A61J1/2096, filling of medical containers in general B65B3/003
• CPC Class Codes: A61M 5/2046 Media being expelled from injector by gas generation, e.g. explosive charge
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/2455 with sealing means to be broken or opened
• CPC Class Codes: A61M 5/28 Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/31596 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/3213 Caps placed axially onto the needle, e.g. equipped with finger protection guards axially-extensible protective sleeves A61M5/3243
• CPC Class Codes: A61M 5/3232 Semi-automatic needle retraction, i.e. in which triggering of the needle retraction requires a deliberate action by the user, e.g. manual release of spring-biased retraction means

Abstract

A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments and a fitment. The first compartment contains at least a first constituent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.

Claims

1-112. -112. (canceled)

113. A pre-filled cap for enclosing an administration portion of a beneficial agent delivery device comprising a reservoir, said pre-filled cap comprising:

a package comprising;

at least a first compartment containing at least one constituent of a beneficial agent; and

a fluid passageway for communicating said first compartment with said administration portion.

114. The pre-filled cap of claim 113, wherein said first compartment includes a wall, and at least a portion of said wall comprises a flexible material.

115. The pre-filled cap of claim 114 wherein said flexible material comprises a webbing.

116. The pre-filled cap of claim 113 wherein said first compartment contains a first constituent of the beneficial agent, and further comprising a second compartment containing a second constituent of the beneficial agent, and comprising an openable closure separating said first and second constituents.

117. The pre-filled cap of claim 113 wherein the administration portion comprises one of a needle, a catheter, a tube, a connector, a Luer connector, a nozzle, a jet injector nozzle, a dispenser, an oral dispenser, an ocular dispenser, an auricular dispenser, a topical dispenser, a micro-needle, an ID needle, an IM needle, a SQ needle, a safety needle, a retractable needle, a needle with a protective sleeve, and a coupler to one of the formers.

118. The pre-filled cap of claim 113 further comprising a closure that separates said first compartment and the administration portion until said closure is opened.

119. The pre-filled cap of claim 113 further comprising a fluid passageway.

120. The pre-filled cap of claim 119 further comprising a membrane occluding said fluid passageway.

121. The pre-filled cap of claim 120 wherein the administration portion comprises a needle that is movable to pierce said membrane to establish fluid communication with said fluid passageway.

122. The pre-filled cap of claim 120 wherein the administration portion comprises a needle configured to pierce said membrane to establish fluid communication with said fluid passageway.

123. The pre-filled cap of claim 113 further comprising a backing for at least a portion of said package.

124. The pre-filled cap of claim 113 wherein said first compartment is formed in a package comprising a fitment.

125. The pre-filled cap of claim 124 wherein at least a portion of said package comprises a webbing.

126. The pre-filled cap of claim 124, wherein said beneficial agent delivery device provide a unit dose.

127. The pre-filled cap of claim 124, wherein said beneficial agent delivery device comprises a unitary reservoir.

128-228. -228. (canceled)

229. A method for producing a prefillable container, comprising:

forming a sealed cavity comprising at least a first compartment and at least a first filling compartment interconnected in fluid communication via a sealable first filling channel;

piercing a wall of the filling compartment with a filling device and filling a constituent into the first compartment via the first filling channel; and

sealing said first filling channel when said filling step is completed.

230. The method of claim 229 further comprising removing a portion of the container that comprises said filling compartment.

231. The method of claim 229 wherein the cavity further comprises at least a second filling compartment interconnected in fluid communication with the first compartment, the method further comprising piercing the wall of said second filling compartment to allow gas to evacuate from the first compartment while the first compartment is filled with the constituent, and sealing the second channel when the filing is completed.

232. The method of claim 229 wherein the container comprises a first pre-formed web wall joined with a second wall to define said sealed cavity.

234. The method of claim 229 wherein the container is blow molded.

233. (canceled)

235-255. -255. (canceled)