ABUSE DETERRENT PHARMACEUTICAL COMPOSITIONS FOR CONTROLLED RELEASE
First Claim
Patent Images
1. An abuse-deterrent pharmaceutical composition, comprising:
- (a) at least one active drug substance;
(b) at least one polyethylene oxide; and
(c) at least one plasticizer;
wherein the pharmaceutical composition does not provide immediate release of the at least one active drug substance after physical tampering;
wherein the at least one polyethylene oxide has an average molecular weight of at least 1,000,000 daltons, andwherein the pharmaceutical composition comprises at least 5% w/w of the at least one plasticizer.
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Accused Products
Abstract
The present disclosure relates to pharmaceutical compositions that are abuse resistant and may also provide controlled release. The present disclosure also relates to the use of pharmaceutical compositions in the treatment of pain.
32 Citations
44 Claims
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1. An abuse-deterrent pharmaceutical composition, comprising:
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(a) at least one active drug substance; (b) at least one polyethylene oxide; and (c) at least one plasticizer; wherein the pharmaceutical composition does not provide immediate release of the at least one active drug substance after physical tampering; wherein the at least one polyethylene oxide has an average molecular weight of at least 1,000,000 daltons, and wherein the pharmaceutical composition comprises at least 5% w/w of the at least one plasticizer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. An abuse-deterrent pharmaceutical composition, comprising:
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(a) at least one active drug substance; (b) at least one polyethylene oxide; wherein the pharmaceutical composition does not provide immediate release of the at least one active drug substance after physical tampering; and wherein the at least one polyethylene oxide has a molecular weight of less than about 1,000,000 daltons. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. An abuse-deterrent pharmaceutical composition, comprising:
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(a) at least one active drug substance selected from opioids or pharmaceutically acceptable salts or solvates thereof; (b) at least one polyethylene oxide having an average molecular weight of about 400,000 daltons; wherein the pharmaceutical composition does not provide immediate release of the at least one active drug substance after physical tampering; and wherein physical tampering comprises any kind of physical interference or manipulation that may result in particle size reduction of the pharmaceutical composition. - View Dependent Claims (41)
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42. An abuse-deterrent pharmaceutical composition, comprising:
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(a) at least one active drug substance selected from opioids or pharmaceutically acceptable salts or solvates thereof; (b) at least one polyethylene oxide having an average molecular weight of about 600,000 daltons; wherein the pharmaceutical composition does not provide immediate release of the at least one active drug substance after physical tampering; and wherein physical tampering comprises any kind of physical interference or manipulation that may result in particle size reduction of the pharmaceutical composition. - View Dependent Claims (43)
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44. An abuse-deterrent pharmaceutical composition, comprising:
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(a) at least one active drug substance selected from opioids or pharmaceutically acceptable salts or solvates thereof; (b) at least one polyethylene oxide having an average molecular weight of about 2,000,000 daltons; and (c) at least one plasticizer selected from poloxamer 188, poloxamer 407, and mixtures thereof; wherein the pharmaceutical composition comprises at least 5% w/w of the at least one plasticizer; wherein the pharmaceutical composition does not provide immediate release of the at least one active drug substance after physical tampering; and wherein physical tampering comprises any kind of physical interference or manipulation that may result in particle size reduction of the pharmaceutical composition.
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Specification